Biology of the Cancer CellBy
- G.H. Heppner, Breast Cancer Biology Program, Michigan Cancer Foundation, Detroit, MI, USA
With the current emphasis in cancer research on oncogenes and suppressor genes, and on autocrine factors and their receptors, it is easy to conclude that the "whole story"can be read in the cancer cell per se. No one would deny that the tremendous recent advances in describing the molecular and cellular alterations in cancer cells have greatly added to our understanding of neoplasia. But, learning how to translate the meaning of these alterations into ways of treating and, better yet, preventing cancer will require at least as deep an understanding of the context in which it develops. The topics of this volume were selected to lead the reader through the complex series of events by which cancer cells and their "environment"interact to produce malignant disease. Underlying themes are the diversity in the pathways that can lead to malignancy and the basic heterogeneity of neoplastic cell populations. As has often been said, in cancer no generalizations are always true (including this one). Thus, the various chapters must be viewed as examples of possible processes and mechanisms, not as universally applicable laws.
Advances in Molecular and Cell Biology
Published: March 1994
- Contents. List of Contributors. Preface (G.H. Heppner). Cellular Genetic Alterations: Models of Breast and Colon Cancer (S.R. Wolman and D.W. Visscher). Altered Expression of Transforming Growth Factor-a and Transforming Growth Factor-ß Autocrine Loops in Cancer Cells (M.G. Brattain, K.M. Mulder, S.P. Wu, G. Howell, L. Sun, J.K.V. Willson, and B.L. Ziober). Altered Signal Transduction in Carcinogenesis (C.A. O'Brian, N.E. Ward, and C.G. Ioannides). The Significance of the Extracellular Matrix in Mammary Epithelial Carcinogenesis (C.D. Roskelley, O.W. Petersen, and M.J. Bissell). Epithelial-Stromal Cell Interactions and Breast Cancer (S.Z. Haslam, L.J. Counterman, and K.A. Nummy). The Tissue Matrix and the Regulation of Gene Expression in Cancer Cells (K.J. Pienta, B.C. Murphy, R.H. Getzenberg, and D.S. Coffey). Tumor Cell Interactions in Cancer Growth and Expression of the Malignant Phenotype (F.R. Miller and B.E. Miller). Effects of Class 1 MHC Gene Products on the Immunobiological Properties of BL6 Melanoma Cells (M. Kim and E. Gorelik). The Role of Angiogenesis in Tumor Progression and Metastasis (J.W. Rak, E.J. Hegmann, and R.S. Kerbel). Index.