Biology of Serpins

Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. This volume of Methods in Ezymology is split into 2 parts and comprehensively covers the subject.
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Researchers and students in cell, molecular and developmental biology


Book information

  • Published: July 2011
  • ISBN: 978-0-12-386471-0

Table of Contents

  1. Analysis of Serpin Secretion, Misfolding and Surveilance in the Endoplasmic Reticulum
  2. Shujuan Pan, Michael J. Iannotti and Richard N. Sifers

  3. Serpin-Enzyme Receptors: Ldl Receptor Related Protein 1
  4. Dudley K. Strickland, Selen Catania Muratoglu and Toni M. Antalis

  5. The Role of Autophagy in Alpha-1-Antitrypsin Deficiency
  6. Tunda Hidvegi, Amitava Mukherjee, Michael Ewing, Carolyn Kemp and David H. Perlmutter

  7. Serpins and the Complement System
  8. László Beinrohr, Thomas A. Murray-Rust, Leanne Dyksterhuis, Péter Závodszky, Péter Gál, Robert N. Pike and Lakshmi C. Wijeyewickrema

  9. Use of Mouse Models to Study Plasminogen Activator Inhibitor-1
  10. Paul J. Declerck, Ann Gils and Bart De Taeye

  11. Plasminogen Activator Inhibitor Type 2: Still An Enigmatic Serpin But A Model For Gene Regulation
  12. Robert L. Medcalf

  13. The Serpinb1 Knock-Out Mouse: A Model For Studying Neutrophil Protease Regulation in Homeostasis and Inflammation
  14. Charaf Benarafa

  15. Investigating Maspin in Breast Cancer Progression Using Mouse Models
  16. Michael P. Endsley and Ming Zhang

  17. Hsp47as A Collagen-Specific Molecular Chaperone
  18. Yoshihito Ishida and Kazuhiro Nagata

  19. Assays for the Antiangiogenic and Neurotrophic Serpin Pigment Epithelium‚ÄźDerived Factor
  20. S. Patricia Becerra, Susan E. Crawford and Preeti Subramanian

  21. The Drosophila Serpins: Multiple Functions in Immunity and Morphogenesis
  22. Jean Marc Reichhart, David Gubb and Vincent Leclerc

  23. Modelling Serpin Conformational Diseases in Drosophila Melanogaster
  24. Thomas R. Jahn, Elke Malzer, John Roote, Anastasia Vishnivetskaya, Sara Imarisio, Maria Giannakou, Karin Panser, Stefan Marciniak, Damian C. Crowther

  25. Using Caenorhabditis Elegans to Study Serpinopathies
  26. Olivia S. Long, Sager J. Gosai, Joon Hyeok Kwak, Dale E. King, David H. Perlmutter, Gary A. Silverman and Stephen C. Pak

  27. Using c. Elegans to Identify the Protease Targets of Serpins In Vivo.
  28. Sangeeta R. Bhatia, Mark T. Miedel, Cavita K. Chotoo, Nathan J. Graf, Brian L. Hood, Thomas P. Conrads, Gary A. Silverman and Cliff J. Luke

  29. Viral Serpin Therapeutics: From Concept to Clinic
  30. Hao Chen, MD, PhD, Donghang Zheng, MD, PhD, Jennifer Davids, BA, Mee Yong Bartee, PhD, Erbin Dai, MD, Liying Liu, MD, Lyubomir Petrov, MD, PhD, Colin Macaulay, PhD, Robert Thoburn, MD, Eric Sobel, MD, PhD, Richard Moyer, PhD, Grant McFadden, PhD, Alexandra Lucas, MD, FRCP(C)

  31. Human Scca Serpins Inhibit Staphylococcal Cysteine Proteases by Forming Classic "Serpin-Like" Covalent Complexes
  32. Tomasz Kantyka and Jan Potempa

  33. Plants and the Study of Serpin Biology

Thomas H. Roberts, Joon-Woo Ahn, Nardy Lampl and Robert Fluhr