Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease book cover

Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease

Prevention and Therapy

Nutritional supplement research concerning brain health and neurological disease is becoming an important focus. While nutritional supplements are very popular for general health and well being, the effectiveness of common supplements and their impact on general brain health and for the treatment or prevention of neurological disease is not clearly understood. This comprehensive introduction to bioactive nutraceuticals for brain and neurological provides a foundation review for research neuroscientists, clinical neurologists, pharmacology researchers and nutrition scientists on what we know now about these supplements and the brain and where focused research is still necessary.


Neuroscience\Neurology Research, Nutrition Research

Hardbound, 528 Pages

Published: September 2014

Imprint: Academic Press

ISBN: 978-0-12-411462-3


  • Section 1: Role of Complementary and alternative supplements: Overview of mechanisms of action and neurological targets
    1. Anti-inflammatory properties of botanical extracts contribute to their protective effects in brain edema in cerebral ischemia
      Kiran S. Panickar
    2. Blueberry polyhphenols and neuroprotection
      Marilù Giacalone, Filippo Di Sacco, Ippolito Traupe, Nicola Pagnucci, Francesco Forfori and Francesco Giunta
    3. Neuropharmacology effects of saffron (Crocus sativus) and its active constituents
      Marjan Nassiri-Asl and Hossein Hosseinzadeh
    4. Lutein, brain and neurological functions
      Vijaya Juturu
    5. Bioactive nutrients for Brain health: an overview
      Vijaya Juturu
    6. The use of Paullinia cupana  (Guarana) to treat fatigue and other symptoms of cancer and cancer treatment
      Adriana del Giglio and Auro del Giglio
    7. Polyphenols, Nerve Growth factor, Brain-derived Neurotrophic Factor and the Brain
      Valentina Carito, Mauro Ceccanti, George Chaldakov, Luigi Tarani, Sara De Nicolò, Stefania Ciafrè, Paola Tirassa and Marco Fiore
    8. The anti-aggregative, anti-amyloid properties of bioactive polyphenols in the treatment of Alzheimer ’s disease
      Sukanya Das and Scott D. Smid
    9. Rhinacanthus nasutus extract as a neuroprotectant
      James M. Brimson and Tewin Tencomnao

    Section 2: Role of diets, complementary, and alternative supplements in prevention and treatment of neurodegenerative diseases
    10. Nutraceuticals, dietary supplements and functional foods as alternatives to the relief of neuropathic pain
      Gislaine Francieli da Silva, Lilian Wunsch Rocha and Nara Lins Meira Quintão
    11. The Therapeutic Activities of Selected Scrophulariaceae and Buddlejaceae Species As Well As Their Secondary Metabolites Against Neurodegenerative Diseases                    
      I. Irem Tatli, Cigdem Kahraman and Zeliha Sükran Akdemir
    12. Ginkgo biloba Extracts in Neurological Disorders Therapy: Clinical Trials
      I. Irem Tatli
    13. The Ketogenic Diet for the Adjuvant Treatment of Malignant Brain Tumors                        
      Eric C. Woolf and Adrienne C. Scheck
    14. Reduction is the new young! The effect of polyphenols on brain ageing and diseases
      Lakshana Sreenivasan and Ronald R. Watson
    15. Natural sleep aids and polyphenols as treatments for insomnia
      Suengmok Cho and Makoto Shimizu
    16. The effects of trace elements deficiencies on neurological disease and treatment with trace elements support
      Aysegül Bayir
    17. Nutritional supplementations in Ehlers-Danlos syndromes
      Marco Castori, Michela Bruschini and Carlo Blundo

    Section 3: Mood and cognition by nutriceutical interventions
    18. Ayurvedic approach to food and dietary supplements in brain and neurological health
      Hari Sharma and H. M Chandola
    19. The effect of acai (Euterpe spp.) fruit pulp on brain health and performance
      Alexander G. Schauss
    20. Chili pepper compounds in the management of neuropathic pain
      Marilù Giacalone, Francesco Forfori and Francesco Giunta
    21. Curcumin and neurological/brain disorders
      Federico Franceschi, Stefano Togni and Giovanni Appendino

    Section 4: Drug and foods and nutriceutical interactions during treatment of neurodegenerative diseases: Toxicities
    22. The effects of taurine exposure effects on the brain and neurological disorders  
      Sanya Roysommuti and James Michael Wyss
    23. Adverse neurologic effects caused by the ingestion of plants, seeds and fruits         
      Francisco Javier Carod Artal
    24. Molecular mechanisms of geniposide and genipin against Alzheimer’s disease
      Jianhui Liu, Fei Yin, Lixia Guo, Junzeng Zhang and Jeffrey Zidichouski
    25. Flavones and flavonols in brain and disease: facts and pitfalls
      Florencia Arredondo, Carolina Echeverry, Fernanda Blasina, Lucía Vaamonde, Marcela Díaz, Marcela Martínez, Juan Andres Abin-Carriquiry and Federico Dajas
    26. Mercury and neurodegeneration 
      Michael Aschner
    27. Ameliorative Effects of Nutraceuticals in Neurological Disorders
      Neelima B. Chauhan and Jogender Mehla
    28. Roles of Caffeine in Neurodegenerative Diseases: Possible Genetic and Cellular Signaling Mechanisms
      Khanh v.q. LÆ°Æ¡ng and Lan Thi Hoàng Nguyễn
    29. Dietary supplements as cognitive enhancers: role of flavonoid-rich foods and their relevance in age-related neurodegeneration
      Krishna Gokul and M. Muralidhara

    Section 5: Mechanisms of action of nutriceuticals and dietary supplements in neurological disease therapy: Autoimmunity and antioxidant actions
    30. Meats, fats and fruit consumption and autoimmune neurological and brain disease
      Ronald R. Watson and Gurman Dhaliwal
    31. Ginsenosides as food supplements and their potential role in immunological and neurodegenerative disorders
      Salman Kahn, Alev -. Tosun and Yeong Shik Kim
    32. Antioxidant actions of spices and their phytochemicals on age-related Diseases
      Alev -. Tosun and Salman Kahn
    33. Analgesic and anti-inflammatory effects of Crocus sativus L., (saffron)
      Bahareh Amin and Hossein Hosseinzadeh
    34. Electrophilic derivatives of omega-3 fatty acids for the cure and prevention of neurodegenerative disorders
      Chiara Cipollina and Francisco J. Schopfer
    35. Antioxidants in the prevention and treatment of multiple sclerosis: an overview
      C. Zuliani and Luciana Baroni
    36. High Caloric Diets in Amyotrophic Lateral Sclerosis
      S. T. Ngo, F. J. Steyn, P. A. McCombe and Karin Borges

    Section 6:  Hypertension and Stroke
    37. Bioactive Nutriceuticals and Stroke: Activation of Endogenous Antioxidant Pathways and Molecular Mechanisms Underlying Neurovascular Protection
      Alessio Alfieri and Giovanni E. Mann
    38. Oral feeding in patients with intracerebral hemorrhage: Risk versus benefits
      Hideaki Takahata
    39. Neuroprotection by dietary isoflavones: Role in cerebral ischemia
      Derek A. Schreihofer
    40. Vitamin K antagonists (VKA), i.e. coumarins, drugs used in prevention and treatment of cardioembolism, deep vein thrombosis and pulmonary embolism
      Francesco Marongiu and Doris Barcellona
    41. Prevention of ischemia-induced neuronal apoptosis by vitamin E in stroke-prone spontaneously hypertensive rats- cellular mechanisms of antioxidant
      Kazuo Yamagata and Motoki Tagami
    42. Diet, stroke, and traumatic brain injury 
      Joseph L. Cheatwood, R. W. Clough and W. J. Banz

    Section 7: Seizures, epilepsy, Parkinson disease
    43. A plant-food diet in the risk and management of Parkinson's Disease
      Luciana Baroni and C. Zuliani
    44. Nutraceuticals and other natural products in Parkinson's disease therapy:  focus on clinical applications
      R.B. Mythri, A.K. Joshi and M.M. Srinivas Bharath
    45. Ketogenic diet treatment in adults with refractory epilepsy
      Ivana Tyrlikova and Pavel Klein
    46. Ketogenic diets for the treatment of epilepsy
      Ricka D. Messer and Eric H. Kossoff
    47. Nutritional/metabolic therapies in animal models of ALS, Alzheimer's disease and seizures
      Csilla Ari, Raffaele Pilla and Dominic D'Agostino
    48. Metabolic dysfunctions in epilepsy and novel metabolic treatment approaches                             
      Kah Ni Tan, Tanya S McDonald and Karin Borges
    49. Vitamin D for the prevention of Alzheimer's disease
      Elizabeth Pogge
    50. Is multiple sclerosis a sun Deprivation disease? Lessons from the past for the future path
      Tirang Reza Neyestani


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