Basic Neurochemistry

Principles of Molecular, Cellular, and Medical Neurobiology

Edited by

  • Scott Brady, University of Illinois, Chicago IL
  • George Siegel, Loyola University, Chicago, IL, USA
  • R. Wayne Albers, National Institutes of Health, Bethesda MD, USA
  • Donald Price, The Johns Hopkins University School of Medicine, Baltimore MD

Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease.

This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology.

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Advanced undergraduates, graduate students and post-docs in neuroscience or biomedical science, medical students, clinical neuroscientists and neurologists


Book information

  • Published: December 2011
  • ISBN: 978-0-12-374947-5

Table of Contents

Part I: Cellular Neurochemistry and Neural Membranes
Cell Biology of the Nervous System
Cell Membrane Structures and Functions
Membrane Transport
Electrical Excitability and Ion Channels
The Cytoskeleton of Neurons and Glia
Intracellular Trafficking
Axonal Transport
Cell Adhesion Molecules
Myelin Structure and Biochemistry
Energy Metabolism of the Brain

PART II: Intercellular Signaling
Synaptic Transmission and Cellular Signaling: An Overview
Glutamate and Glutamate Receptors
Purinergic Signaling

PART III: Intracellular Signaling
G Proteins
Cyclic Nucleotides in the Nervous System
Serine and Threonine Phosphorylation
Tyrosine Phosphorylation
Transcription Factors in the Central Nervous System

PART IV: Growth, Development and Differentiation
Development of the Nervous System
Growth Factors
Stem Cells in the Nervous System
Formation and Maintenance of Myelin
Axonal Growth in the Adult Mammalian Nervous System

PART V: Cell Injury and Inflammation
Molecular Mechanisms and Consequences of Immune and Nervous System Reactions
Brain Ischemia and Reperfusion: Cellular and Molecular Mechanisms in Stroke Injury
Lipid Mediators: Eicosanoids, Docosanoids and Platelet-Activating Factor
Apoptosis and Necrosis

PART VI: Inherited and Neurodegenerative Diseases
Peripheral Neuropathy
Diseases Involving Myelin
The Epilepsies: Phenotypes and Mechanisms
Genetics of Neurodegenerative Diseases
Disorders of Amino Acid Metabolism
Inborn Metabolic Defects of Lysosomes, Peroxisomes, Carbohydrates, and Fatty Acids and Mitochondria
Disorders of Muscle Excitability
Motor Neuron Diseases
Neurobiology of Alzheimer's Disease
Synucleinopathies and Tauopathies
Cellular and Molecular Basis of Neurodegeneration in the CAG-Polyglutamine Repeat Diseases
Neurotransmitters and Disorders of the Basal Ganglia
Molecular Basis of Prion Diseases

PART VII: Sensory Transduction
Molecular Biology of Vision
Molecular Biology of Olfaction and Taste
Molecular Biology of Hearing and Balance

PART VIII: Neural Processing and Behavior
Endocrine Effects on the Brain and Their Relationship to Behavior
Learning and Memory
The Neurochemistry of Sleep and Wakefulness
The Neurochemistry of Schizophrenia
The Neurochemistry of Autism
Neurobiology of Severe Mood and Anxiety Disorders