Basic Neurochemistry book cover

Basic Neurochemistry

Principles of Molecular, Cellular, and Medical Neurobiology

Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease.

This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology.

Advanced undergraduates, graduate students and post-docs in neuroscience or biomedical science, medical students, clinical neuroscientists and neurologists

Hardbound, 1120 Pages

Published: December 2011

Imprint: Academic Press

ISBN: 978-0-12-374947-5


  • Part I: Cellular Neurochemistry and Neural Membranes
    Cell Biology of the Nervous System
    Cell Membrane Structures and Functions
    Membrane Transport
    Electrical Excitability and Ion Channels
    The Cytoskeleton of Neurons and Glia
    Intracellular Trafficking
    Axonal Transport
    Cell Adhesion Molecules
    Myelin Structure and Biochemistry
    Energy Metabolism of the Brain

    PART II: Intercellular Signaling
    Synaptic Transmission and Cellular Signaling: An Overview
    Glutamate and Glutamate Receptors
    Purinergic Signaling

    PART III: Intracellular Signaling
    G Proteins
    Cyclic Nucleotides in the Nervous System
    Serine and Threonine Phosphorylation
    Tyrosine Phosphorylation
    Transcription Factors in the Central Nervous System

    PART IV: Growth, Development and Differentiation
    Development of the Nervous System
    Growth Factors
    Stem Cells in the Nervous System
    Formation and Maintenance of Myelin
    Axonal Growth in the Adult Mammalian Nervous System

    PART V: Cell Injury and Inflammation
    Molecular Mechanisms and Consequences of Immune and Nervous System Reactions
    Brain Ischemia and Reperfusion: Cellular and Molecular Mechanisms in Stroke Injury
    Lipid Mediators: Eicosanoids, Docosanoids and Platelet-Activating Factor
    Apoptosis and Necrosis

    PART VI: Inherited and Neurodegenerative Diseases
    Peripheral Neuropathy
    Diseases Involving Myelin
    The Epilepsies: Phenotypes and Mechanisms
    Genetics of Neurodegenerative Diseases
    Disorders of Amino Acid Metabolism
    Inborn Metabolic Defects of Lysosomes, Peroxisomes, Carbohydrates, and Fatty Acids and Mitochondria
    Disorders of Muscle Excitability
    Motor Neuron Diseases
    Neurobiology of Alzheimer's Disease
    Synucleinopathies and Tauopathies
    Cellular and Molecular Basis of Neurodegeneration in the CAG-Polyglutamine Repeat Diseases
    Neurotransmitters and Disorders of the Basal Ganglia
    Molecular Basis of Prion Diseases

    PART VII: Sensory Transduction
    Molecular Biology of Vision
    Molecular Biology of Olfaction and Taste
    Molecular Biology of Hearing and Balance

    PART VIII: Neural Processing and Behavior
    Endocrine Effects on the Brain and Their Relationship to Behavior
    Learning and Memory
    The Neurochemistry of Sleep and Wakefulness
    The Neurochemistry of Schizophrenia
    The Neurochemistry of Autism
    Neurobiology of Severe Mood and Anxiety Disorders


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