Basic aspects of Catechol-O-methyltransferase and the clinical applications of its inhibitors book cover

Basic aspects of Catechol-O-methyltransferase and the clinical applications of its inhibitors

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

Neuroscientists, neurologists, psychologists, gerontologists

Hardbound, 336 Pages

Published: December 2010

Imprint: Academic Press

ISBN: 978-0-12-381326-8


    1. Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinson’s disease with dual enzyme inhibition
    2. Erkki Nissinen

    3. The catechol-O-methyltransferase gene, its regulation and polymorphisms
    4. Elizabeth M. Tunbridge

    5. Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture?
    6. Timo T. Myöhänen & Pekka T. Männistö

    7. Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms
    8. Thomas Müller

    9. Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors
    10. Erkki Nissinen and Pekka T. Männistö

    11. The Chemistry of Catechol-O-methyltransferase Inhibitors
    12. David A. Learmonth, László E. Kiss and Patrício Soares-da-Silva

    13. Toxicology and safety of COMT inhibitors
    14. Kristiina Haasio

    15. Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment
    16. Concepció Marin, J.A. Obeso

    17. Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson’s disease
    18. Seppo Kaakkola

    19. Catechol-O-methyltransferase and pain

    Oleg Kambur & Pekka T. Männistö


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