Autophagy in Disease and Clinical Applications

Part C

Edited by

  • Daniel Klionsky, Life Sciences Institute, University of Michigan, USA

The third and final installment of Daniel J. Klionsky's new three-volume treatment of autophagy, this volume focuses on monitoring autophagy with regard to disease connections, and presents methods that can be used to analyze autophagy in clinical samples. Edited by one of the leading authorities in the field, this volume and its companion volumes, Autophagy: Lower Eukaryotes and Autophagy in Mammalian Systems, provide a comprehensive overview of the techniques involved in studying autophagy in eukaryotes and simple animal systems, mammalian cells and non-human animals, and humans. Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal “house cleaning” in the cell is called autophagy - literally self-eating. In the future, research in this field will help to design clinical approaches that can turn on autophagy and halt tumor growth.
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Researchers and students in biochemistry, cell and molecular biology, oncology, pharmacology


Book information

  • Published: February 2009
  • ISBN: 978-0-12-374936-9

Table of Contents

1. Initiation of Autophagy by Photodynamic TherapyNancy L. Oleinick and David Kessel2. Autophagic cell deathMichael Lenardo and Li Yu3. Autophagic neuron deathYasuo Uchiyama, Masato Koike, Masahiro Shibata, and Mizuho Sasaki4. Assessing Metabolic Stress and Autophagy Status in Epithelial TumorsRobin Mathew, Vassiliki Karantza-Wadsworth and Eileen White5. Autophagic clearance of aggregate–prone proteins associated with neurodegenerationSovan Sarkar, Brinda Ravikumar and David Rubinsztein6. Monitoring Autophagy in Alzheimer's Disease and Related Neurodegenerative Diseases Sovan Dun-Sheng Yang, Ju-Hyun Lee; Ralph A. Nixon7. Live-cell imaging of autophagy induction and autophagosome-lysosome fusion in primary cultured neuronsMona Bains and Kim A. Heidenreich8. Using Genetic Mouse Models to Study the Biology and Pathology of Autophagy in the Central Nervous SystemZhenyu Yue*, Gay R. Holstein, Brian T. Chait and Qing Jun Wang9. Biochemical and Morphological Detection of Inclusion Bodies in Autophagy-deficient MiceMasaaki Komatsu and Satoshi Waguri10. Analyzing Autophagy in Clinical Tissues of Lung and Vascular DiseasesAugustine Choi, Zhi Hua Chen, Hong Pyo Kim and Stefan Ryter11. Autophagy in Neurite Injury and Neurodegeneration: in vitro and in vivo modelsCharleen T. Chu, Edward D. Plowey, Robert W. Hickey, Ruben K. Dagda and Robert S.B. Clark12. MONITORING THE AUTOPHAGY PATHWAY IN CANCERJohn L. Cleveland, Frank Dorsey and Meredith Steeves13. Autophagy pathways in glioblastomaHong Jiang, Erin White, Charles Conrad, Candelaria Gomez-Manzano and Juan Fueyo14. Autophagy in Lung CancerBo Lu15. Signal-dependent control of autophagy-related gene expressionFulvio Chiacchiera and Cristiano Simone16. Novel Methods for Measuring Cardiac Autophagy in vivoRoberta A. Gottlieb and Junichi Sadoshima17. Autophagy in Load-Induced Heart DiseaseHongxin Zhu, Beverly A. Rothermel and Joseph A. Hill18. EVALUATION OF CELL DEATH MARKERS IN SEVERE CALCIFIED AORTIC VALVESWilhelm P. Mistiaen and Michiel W.M. Knaapen 19. Monitoring autophagy in muscle diseasesIchizo Nishino, May Malicdan and Satoru Noguchi20. Analyzing Macroautophagy in Hepatocytes and the LiverXiao-Ming Yin21. Monitoring Autophagy in Lysosomal Storage DisordersNina Raben, Victoria Hill, Lauren Shea and Paul Plotz