Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging book cover

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Volume 3 - Mitophagy

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections.


Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration.  From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.

Hardbound, 432 Pages

Published: January 2014

Imprint: Academic Press

ISBN: 978-0-12-405529-2

Contents

  • 1: INTRODUCTION
    2: AUTOPHAGIC FLUX, FUSION DYNAMICS AND CELL DEATH
    3: ARCHITECTURE OF THE ATG12-ATG5-ATG16 COMPLEX AND ITS MOLECULAR ROLE IN AUTOPHAGY
    4: THE MOLECULAR MECHANISMS UNDERLYING AUTOPHAGOSOME FORMATION IN YEAST
    5: ROLE OF AUTOPHAGY IN CELL SURVIVAL IN LIVER INJURY
    6: POLYMORPHISMS IN AUTOPHAGY-RELATED GENES IN CROHN’S DISEASE: IMPACT ON INTRACELLULAR BACTERIA PERSISTENCE AND INFLAMMATORY RESPONSE
    7: FUNCTIONAL RELEVANCE OF AUTOPHAGINS IN LIFE AND DISEASE
    8: STRATEGIES TO BLOCK AUTOPHAGY IN TUMOUR CELLS
    9: AUTOPHAGIC DYSFUNCTION IN GAUCHER DISEASE AND ITS RESCUE BY CATHEPSIN B AND D PROTEASES
    10: CARGO RECOGNITION FAILURE UNDERLIES MACROAUTOPHAGY DEFECTS IN HUNTINGTON’S DISEASE
    11: HEPATITIS C VIRUS INFECTION, AUTOPHAGY AND INNATE IMMUNE RESPONSE 
    12: GERANYLGERANOIC ACID INDUCES INCOMPLETE AUTOPHAGY BUT LEADS TO THE ACCUMULATION OF AUTOPHAGOSOMES IN HUMAN HEPATOMA CELLS
    13: DEFENSE AGAINST PROTEOTOXIC STRESS IN THE HEART: ROLE OF P62, AUTOPHAGY, AND UBIQUITIN-PROTEASOME SYSTEM
    14: ELIMINATION OF INTRACELLULAR BACTERIA BY AUTOPHAGY
    15: PROTEIN PHOSPHATASE 2A HAS POSITIVE AND NEGATIVE ROLES IN AUTOPHAGY
    16: ERUFOSINE INDUCES AUTOPHAGY AND APOPTOSIS IN ORAL SQUAMOUS CELL CARCINOMA: ROLE OF THE AKT-MTOR SIGNALING
    17: EMERGING ROLE OF HYPOXIA-INDUCED AUTOPHAGY IN CANCER IMMUNOTHERAPY
    18: INVOLVEMENT OF AUTOPHAGY AND APOPTOSIS IN STUDIES OF ANTICANCER DRUGS
    19: AUTOPHAGY-BASED PROTEIN BIOMARKERS FOR IN VIVO DETECTION OF CARDIOTOXICITY IN THE CONTEXT OF CANCER THERAPY
    20: INHIBITION OF MTOR PATHWAY AND INDUCTION OF AUTOPHAGY BLOCK LYMPHOMA CELL GROWTH: ROLE OF AMPK ACTIVATION
    21: AUTOPHAGY REGULATES OSTEOARTHRITIS-LIKE GENE EXPRESSION CHANGES: ROLE OF APOPTOSIS AND REACTIVE OXYGEN SPECIES
    22: THE KEY ROLE OF AUTOPHAGY AND ITS RELATIONSHIP WITH APOPTOSIS IN LEPIDOPTERAN LARVAL MIDGUT REMODELING
    23: INTERFERON REGULATORY FACTOR 1 REGULATES BOTH AUTOPHAGY AND APOPTOSIS IN SPLENOCYTES DURING SEPSIS
    24: THE INTERPLAY BETWEEN AUTOPHAGY AND APOPTOSIS

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