Autoantibodies

Edited by

  • Yehuda Shoenfeld, Head: Zabludowicz Center for Autoimmune Diseases,Sheba Medical Center, Affiliate of Tel-Aviv University, Israel
  • Pier Luigi Meroni, Department of Clinical Sciences & Community Health, University of Milan, Italy
  • M. Gershwin, MD, Division of Rheumatology, Allergy & Clinical Immunology, University of California at Davis School of Medicine, Davis, CA

Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of Autoantibodies is an in-depth review of the main autoantibodies identified up to now, with particular emphasis on those that display a diagnostic or prognostic clinical value.

The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). This is an ideal reference for anyone involved in the field of autoimmune diseases.

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Audience

Physicians and students in Internal Medicine, Rheumatology, Clinical Immunology, Hematology, Endocrinology, Gastroenterology, Neurology, Nephrology, and Dermatology. Also of interest to those working in companies involved in selling diagnostic assays for autoimmune disorders.

 

Book information

  • Published: December 2013
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-56378-1

Reviews

"...a comprehensive reference covering the most important known autoantibodies, with particular emphasis on those that display a clinical value...fully updated to include recent scientific advances, diagnostic techniques and therapeutic technologies."--Anticancer Research, February 2015

"This is an extraordinary, comprehensive, seminal book that is also easy to read. The extensive research of the last few years has advanced the science in dramatic ways and this book has a unique and unmatched presentation of the current understanding of autoantibodies, and their impact on health and disease and begins the discussion of the available treatment options and possibilities for future research."--Doody.com, July 18, 2014


"Almost completely revised and updated…in relation to recent advances in the field, this is the third edition of a textbook describing clinical and research aspects of autoantibodies. Some 150 specific autoantibodies are reviewed, both in terms of their clinical significance to the practicing physician and in relation to research interest in immunoglobulin self-reactivity against tissue antigens."--ProtoView.com, April 2014




Table of Contents

FOREWORD: THE CONCEPT OF IMMUNODIAGNOSIS

INTRODUCTION:  AUTOANTIBODIES-UNIQUE CHARACTERISTICS

ALLERGIC DISEASE AUTOANTIBODIES

ANTINEUTROPHIL ANTIBODIES

INTRODUCTION: ANTINUCLEAR ANTIBODIES

AUTOANTIBODIES TO BIOLOGIC FACTORS/STRUCTURES

CARDIAC AUTOANTIBODIES

ENDOCRINE AUTOANTIBODIES

GI AND LIVER AUTOANTIBODIES

HEMATOLOGIC AUTOANTIBODIES

KIDNEY AUTOANTIBODIES

NEUROLOGICAL SYSTEM AUTOANTIBODIES

RHEUMATIC DISEASE AUTOANTIBODIES

SKIN DISEASE AUTOANTIBODIES

UNIQUE CLINICAL SITUATIONS