Aulton

Aulton's Pharmaceutics

The Design and Manufacture of Medicines

Pharmaceutics is one of the most diverse subject areas in all of pharmaceutical science. In brief, it is concerned with the scientific and technological aspects of the design and manufacture of dosage forms or medicines. An understanding of pharmaceutics is therefore vital for all pharmacists and those pharmaceutical scientists who are involved with converting a drug or a potential drug into a medicine that can be delivered safely, effectively and conveniently to the patient.

Now in its fourth edition, this best-selling textbook in pharmaceutics has been brought completely up to date to reflect the rapid advances in delivery methodologies by eye and injection, advances in drug formulations and delivery methods for special groups (such as children and the elderly), nanomedicine, and pharmacognosy. At the same time the editors have striven to maintain the accessibility of the text for students of pharmacy, preserving the balance between being a suitably pitched introductory text and a clear reflection of the state of the art.

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Published: June 2013

Imprint: Churchill Livingstone

ISBN: 978-0-7020-4290-4

Contents

  • What is ‘pharmaceutics’? 0

    1. Design of dosage forms 0

    Peter York

    PART 1: Scientific principles of dosage form design 

    2. Dissolution and solubility 00

    Michael E. Aulton

    3. Properties of solutions 00

    Michael E. Aulton

    4. Surfaces and interfaces 00

    Graham Buckton

    5. Disperse systems 00

    David Attwood

    6. Rheology

    Christopher Marriot

    7. Kinetics 00

    W. John Pugh

    PART 2: Particle science and powder technology 00

    8. Solid-state properties 00

    Graham Buckton

    9. Particle size analysis 00

    J.N. Staniforth, Kevin M.G. Taylor

    10. Particle size reduction and size separation 00

    Michael E. Aulton, J.N. Staniforth

    11. Mixing 00

    Andrew M. Twitchell

    12. Powder flow 00

    Michael E. Aulton

    PART 3: Pharmaceutical microbiology and sterilization 00

    13. Fundamentals of microbiology 00

    Geoffrey W. Hanlon

    14. Pharmaceutical applications of microbiological techniques 00

    Norman A. Hodges

    15. Action of physical and chemical agents on microorganisms 00

    Geoffrey W. Hanlon, Norman A. Hodges

    16. Principles of sterilization 00

    Susannah E. Walsh, Jean-Yves Maillard

    17. Sterilization in practice 00

    Jean-Yves. Maillard, Susannah E. Walsh

    PART 4: Biopharmaceutical principles of drug delivery 000

    18. Introduction to biopharmaceutics 000

    Marianne Ashford

    19. Gastrointestinal tract - physiology and drug absorption 000

    Marianne Ashford

    20. Bioavailability - physicochemical and dosage form factors 000

    Marianne Ashford

    21. Assessment of biopharmaceutical properties 000

    Marianne Ashford

    22. Dosage regimens 000

    John H. Collett, Soraya Dhillon

    PART 5: Dosage form design and manufacture 000

    23. Pharmaceutical preformulation 000

    Simon Gaisford

    24. Solutions 000

    Sudaxshina Murdan

    25. Clarification 000

    Andrew M. Twitchell

    26. Suspensions 000

    Susan A. Barker

    27. Emulsions and Creams 000

    Gillian M.Eccleston

    28. Powders, granules and granulation 000

    Michael E. Aulton, Malcolm P. Summers`

    29. Drying 000

    Michael E. Aulton

    30. Tablets and compaction 000

    Göran Alderborn

    31. Modified-release oral drug delivery 000

    Abdul W. Basit, Emma L. McConnell

    32. Coating of tablets and multiparticulates 000

    Stuart C. Porter

    33. Hard capsules 000

    Brian E. Jones

    34. Soft capsules 000

    Keith G. Hutchison, Josephine Ferdinando

    35 Dissolution testing of solid dosage forms

    Abdul W. Basit, Ana Cristina Freire

    36 Parenteral drug delivery

    Robert Lowe

    37. Pulmonary drug delivery 000

    Kevin M. G. Taylor

    38. Nasal drug delivery 000

    Gary P. Martin, Alison B. Lansley

    39. Topical and transdermal drug delivery 000

    Adrian C. Williams

    40. Wound dressings 000

    Gillian M. Eccleston

    41. Ocular drug delivery 000

    Hala Fadda, Ashkan Khalili, Peng T. Khaw, Steve Brocchini

    42. Rectal and vaginal drug delivery 000

    Joseph J. Tukker, Sanjay Garg

    43. Design and administration of medicines for children and the elderly 000

    Catherine Tuleu, David Wright

    44. The formulation and manufacture of plant medicines 000

    G. Brian Lockwood

    45. Pharmaceutical nanotechnology and nanomedicines 000

    Yvonne Perrie

    46. Delivery of biopharmaceuticals 000

    Ijeoma F. Uchegbu, A. G. Shätzlein

    Part 6: PACKAGING AND STABILITY OF PHARMACEUTICAL PRODUCTS

    47. Packaging 000

    Sudaxshina Murdan

    48. Chemical stability in dosage forms 000

    Andrew R. Barnes

    49. Product stability and stability testing 000

    Michael E. Aulton

    50. Microbial contamination, spoilage and preservation of medicines 000

    Norman A. Hodges

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