Asthma and COPD book cover

Asthma and COPD

Basic Mechanisms and Clinical Management

Chronic obstructive pulmonary disease (COPD), which encompasses both chronic bronchitis and emphysema, is one of the most common respiratory conditions of adults in the developed world. Asthma and COPD: Basic Mechanisms and Clinical Management provides a unique, authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it is a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.

Cell biologists, immunologists, pharmacologists, and physicians working in pulmonary research in academia or the pharmaceutical industry.


Published: April 2002

Imprint: Academic Press

ISBN: 978-0-12-079028-9


  • Contents





    Part I: Definitions, Epidemiology, and Genetics of Asthma and COPD

    1 Definitions

    2 Epidemiology

    3 Natural History

    4 Genetics

    Part II: Physiology and Pathology of Asthma and COPD

    5 Pulmonary Physiology

    6 Airway Pathology

    7 Airway Remodeling

    8 Animal Models

    Part III: Inflammatory Cells and Extracellular Matrix

    9 Mast Cells and Basophils

    10 Macrophages

    11 Eosinophils

    12 Lymphocytes

    13 Neutrophils

    14 Fibroblasts

    15 Epithelial Cells

    16 Mucus and Mucin-Secreting Cells

    17 Airway Smooth Muscle

    18 Tracheobronchial Circulation

    19 Pulmonary Vessels

    20 Plasma Exudation

    21 Cell Adhesion Molecules,

    22 Extracellular Matrix

    Part IV: Inflammatory Mediators and Pathways

    23 Prostanoids

    24 Leukotrienes

    25 Kinins

    26 Reactive Oxygen Species

    27 Chemokines

    28 Cytokines

    29 Matrix Degrading Proteinases

    30 Growth Factors

    31 Other Mediators of Airway Disease

    32 Nitric Oxide

    33 Transcription Factors

    34 Neural and Humoral Control

    Part V: Pathogenic Mechanisms in Asthma and COPD

    35 Pathophysiology of Asthma

    36 Pathogenesis of COPD

    Part VI: Triggers of Asthma and COPD

    37 Allergens

    38 Occupational Agents

    39 Infections

    40 Exercise as a Trigger

    41 Atmospheric Pollutants

    42 Drugs

    Part VII: Clinical Assessment of Asthma and COPD

    43 Diagnosis

    44 Non-invasive Assessment of Airway Inflammation

    45 Imaging

    46 Assessment of Disability

    Part VIII: Therapies for Asthma and COPD

    47 Allergen Avoidance

    48 Smoking Cessation

    49 b2-adrenoceptor Agonists

    50 Anticholinergic Bronchodilators

    51 Theophylline

    52 Corticosteroids

    53 Mediator Antagonists

    54 Antibiotics

    55 Long-term Oxygen Therapy

    56 Immunomodulators

    57 Pulmonary Vasodilators

    58 Ventilator Support

    59 Pulmonary Rehabilitation

    60 Surgery

    61 Other Therapies

    62 Future Therapies

    63 Health Economics

    Part IX: Clinical Management of Asthma and COPD

    64 Management of Chronic Asthma in Adults

    65 Acute Exacerbations of Asthma

    66 Childhood Asthma

    67 Treatment for Stable COPD

    68 Acute Exacerbations of COPD

    69 Education and Self-Management



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