Asthma and COPD

Basic Mechanisms and Clinical Management


  • Peter Barnes, DM FRS FMedSci, Head of Respiratory Medicine, Imperial College, London, UK, Airway Disease Section, National Heart and Lung Institute
  • Jeffrey Drazen, Brigham and Women's Hospital, Boston, MA, USA
  • Stephen Rennard, University of Nebraska Medical Center, Omaha, USA
  • Neil Thomson, Western Infirmary, Glasgow, Scotland

Chronic obstructive pulmonary disease (COPD), which encompasses both chronic bronchitis and emphysema, is one of the most common respiratory conditions of adults in the developed world. Asthma and COPD: Basic Mechanisms and Clinical Management provides a unique, authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it is a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.
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Cell biologists, immunologists, pharmacologists, and physicians working in pulmonary research in academia or the pharmaceutical industry.


Book information

  • Published: April 2002
  • ISBN: 978-0-12-079028-9

Table of Contents






Part I: Definitions, Epidemiology, and Genetics of Asthma and COPD

1 Definitions

2 Epidemiology

3 Natural History

4 Genetics

Part II: Physiology and Pathology of Asthma and COPD

5 Pulmonary Physiology

6 Airway Pathology

7 Airway Remodeling

8 Animal Models

Part III: Inflammatory Cells and Extracellular Matrix

9 Mast Cells and Basophils

10 Macrophages

11 Eosinophils

12 Lymphocytes

13 Neutrophils

14 Fibroblasts

15 Epithelial Cells

16 Mucus and Mucin-Secreting Cells

17 Airway Smooth Muscle

18 Tracheobronchial Circulation

19 Pulmonary Vessels

20 Plasma Exudation

21 Cell Adhesion Molecules,

22 Extracellular Matrix

Part IV: Inflammatory Mediators and Pathways

23 Prostanoids

24 Leukotrienes

25 Kinins

26 Reactive Oxygen Species

27 Chemokines

28 Cytokines

29 Matrix Degrading Proteinases

30 Growth Factors

31 Other Mediators of Airway Disease

32 Nitric Oxide

33 Transcription Factors

34 Neural and Humoral Control

Part V: Pathogenic Mechanisms in Asthma and COPD

35 Pathophysiology of Asthma

36 Pathogenesis of COPD

Part VI: Triggers of Asthma and COPD

37 Allergens

38 Occupational Agents

39 Infections

40 Exercise as a Trigger

41 Atmospheric Pollutants

42 Drugs

Part VII: Clinical Assessment of Asthma and COPD

43 Diagnosis

44 Non-invasive Assessment of Airway Inflammation

45 Imaging

46 Assessment of Disability

Part VIII: Therapies for Asthma and COPD

47 Allergen Avoidance

48 Smoking Cessation

49 b2-adrenoceptor Agonists

50 Anticholinergic Bronchodilators

51 Theophylline

52 Corticosteroids

53 Mediator Antagonists

54 Antibiotics

55 Long-term Oxygen Therapy

56 Immunomodulators

57 Pulmonary Vasodilators

58 Ventilator Support

59 Pulmonary Rehabilitation

60 Surgery

61 Other Therapies

62 Future Therapies

63 Health Economics

Part IX: Clinical Management of Asthma and COPD

64 Management of Chronic Asthma in Adults

65 Acute Exacerbations of Asthma

66 Childhood Asthma

67 Treatment for Stable COPD

68 Acute Exacerbations of COPD

69 Education and Self-Management