Antibody Fc:

Linking Adaptive and Innate Immunity

Edited by

  • Margaret Ackerman, Thayer School of Engineering, Dartmouth College Department of Microbiology and Immunology, Geisel School of Medicine
  • Falk Nimmerjahn, Institute of Genetics, Department of Biology, University of Erlangen-Nürnberg

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.

Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.

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vaccinologists, immunologists, microbiologists, oncologists, protein engineers, in academic and industrial research institutions; graduate students in immunology and vaccinology.


Book information

  • Published: September 2013
  • ISBN: 978-0-12-394802-1

Table of Contents

Part 1: Effector Mechanisms
Ch 1: Antibody Dependent Cellular Cytotoxicity
Ch 2: Antibody-Dependent Cellular Phagocytosis and its Impact on Pathogen Control
Ch 3: Interactions between the Complement System and Fcy Receptors

Part 2: Effector Cells
Ch 4: Natural Killer Cells
Ch 5: Phagocytes and Immunoglobulins
Ch 6: B Cells

Part 3: FcR
Ch 7: Structural Recognition of Immunoglobulins by Fcg Receptors
Ch 8: FcyRs Across Species
Part 4: Variability of the Fc Domain
Ch 9: Human IgG Subclasses
Ch 10: Antibody Glycosylation

Part 5: Genetic Associations
Ch 11: Activating and Inhibitory FcyRs in Autoimmune Disorders
Ch 12: Fcg Receptor Polymorphisms and Susceptibility to Infection
Ch 13: Role of IgG Fc Receptors in Monoclonal Antibody Therapy of Cancer

Part 6: Evolving areas
Ch 14: Interactions Among Monoclonal Antibody Mechanisms of Action
Ch 15: Fc Receptor-Dependent Immunity
Ch 16: Fcy Receptors as Therapeutic Targets
Ch 17: Fc Protein Engineering
Ch 18: Bacterial Modulation of Fc Effector Functions
Ch 19: Pathogenic Exploitation of Fc Activity
Ch 20: Mechanisms of Immunoglobulin-Mediated Mucus Entrapment of Pathogens at Various Mucosal Surfaces