Annual Reports in Medicinal Chemistry

Series Editor:

  • John Macor, Neuroscience Discovery Chemistry, Bristol-Myers Squibb, USA

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
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medicinal, pharmaceutical, and organic chemists


Book information

  • Published: October 2008
  • ISBN: 978-0-12-374344-2

Table of Contents

Part I. Central Nervous System Diseases ¨C ROBICHAUDChapter 1 Recent Advances in Corticotropin Releasing Factor Receptor AntagonistsCarolyn D. Dzierba; Richard A. Hartz; Joanne J. BronsonChapter 2 Recent Advances on the 5-HT5A, 5-HT6 and 5-HT7 ReceptorsBrock T. Shireman, Pascal Bonaventure and Nicholas I. CarruthersChapter 3 Recent Advances in Voltage Gated Sodium Channel Blockers: Therapeutic Potential as Drug Targets in the CNSAndreas Termin, Esther Martinborough and Dean WilsonChapter 4 Medication Development for the Treatment of Substance AbuseBrian Fulton Part II. Cardiovascular and Metabolic Diseases - STAMFORDChapter 5 GPR40 (FFAR1) ModulatorsJulio C. Medina and Jonathan B. HouzeChapter 6 Rho-Kinase Inhibitors for Cardiovascular DiseaseRobert A. StavengerChapter 7 LXR Agonists for the Treatment of Atherosclerosis - Recent HighlightsJonathan Bennett, Andrew Cooke, Heather J. McKinnon and Olaf NimzChapter 8 Glucagon Receptor Antagonists for Type II Diabetes DuaneE. DeMong, Michael W. Miller and Jean LachowiczPart III. Inflammation / Pulmonary / GI ¨C BARRISHChapter 9 Advances Towards Dissociated Non-Steroidal Glucocorticoid Receptor AgonistsJohn Regan, Hossein Razavi, David ThomsonChapter 10 Advances in the Discovery of IkB Kinase InhibitorsWilliam J. Pitts and James KempsonChapter 11 Protease Inhibitors for the Potential Treatment of Chronic Obstructive Pulmonary Disease and Asthma Weimin Liu and Eugene HickeyPart IV. Oncology - MYLESChapter 12 mTor Inhibitors in OncologyJeroen Verheijen, Ker Yu and Arie ZaskChapter 13 Oncology Drug Targets in the Sphingomyelin Signaling PathBill Garland, Amy Cavalli and Genevi¨¨ve HansenPart V. Infectious Diseases - PrimeauChapter 14 Inhibitors of Respiratory Syncytial Virus Malcolm Carter and G. Stuart Cockerill Chapter 15 Recent Developments in ¦Â-Lactamases and InhibitorsTarek S. Mansour, Patricia A. Bradford and Aranapakam M. VenkatesanChapter 16 Recent Development in the Treatment of Clostridium Difficile Associated Disease (CDAD)Xicheng Sun, Joseph Guiles and Nebojsa JanjicChapter 17 Recent Advances in the Discovery of Hybrid Antibacterial AgentsMike BarbachynPart VI. Topics in Biology - LOWEChapter 18 Recent Renaissance of Prostaglandin ResearchRobert BurkChapter 19 Human Exposure and Dose ProjectionsPunit H. Marathe, Christine Huang and A. David RodriguesChapter 20 Modeling Networks of Glycolysis, Overall Energy Metabolism and Drug Metabolism under a Systems Biology ApproachZoltan Sarnyai and Laszlo G. Boros Part VII. Topics in Drug Design and Discovery ¨C DESAIChapter 21 Contrasting the Gastrointestinal Tracts of Mammals: Factors that Influence AbsorptionJohn DeSesso and Amy Lavin WilliamsChapter 22 The Emerging Utility of Co-Crystals in Drug Discovery and DevelopmentNicholas MeanwellChapter 23 Pregnane X Receptor: Prediction and Attenuation of Human CYP3A4 Enzyme Induction and Drug-Drug Interactions Michael W. SinzChapter 24 Formulation in Drug Discovery Robert StrictlyPart VIII. To Market, To MarketChapter 25 To Market, To Market - 2007Shridhar Hegde and Michelle Schmidt