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Annual Reports in Medicinal Chemistry
1st Edition, Volume 43 - October 20, 2008
Editor: John E. Macor
Language: English
Paperback ISBN:9780123743442
9 7 8 - 0 - 1 2 - 3 7 4 3 4 4 - 2
eBook ISBN:9780080921877
9 7 8 - 0 - 0 8 - 0 9 2 1 8 7 - 7
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biolog…Read more
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Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
Covers findings related to cardiovascular, inflammation, and pulmonary diseases
Examines issues in oncology, from mTor inhibitors to drug targets
Incorporates up-to-date information on drug design and discovery, including delivery to market
medicinal, pharmaceutical, and organic chemists
Preface
Part I: Central Nervous System Diseases
Chapter 1: Recent Advances in Corticotropin-Releasing Factor Receptor Antagonists
Publisher Summary
1 INTRODUCTION
2 NON-PEPTIDE SMALL MOLECULE CRF-R1 ANTAGONISTS
3 THERAPEUTIC INDICATIONS
4 CLINICAL FINDINGS WITH CRF-R1 ANTAGONISTS
5 SUMMARY
Chapter 2: Recent Advances on the 5-HT5A, 5-HT6 and 5-HT7 Receptors
Publisher Summary
1 INTRODUCTION
2 THE 5-HT5A RECEPTOR
3 THE 5-HT6 RECEPTOR
4 THE 5-HT7 RECEPTOR
5 CONCLUSIONS
Chapter 3: Recent Advances in Voltage-Gated Sodium Channel Blockers: Therapeutic Potential as Drug Targets in the CNS
Publisher Summary
1 INTRODUCTION
2 SODIUM CHANNELS AND THERAPEUTIC OPPORTUNITIES
3 ASSAYS
4 CNS AND PNS SODIUM CHANNEL SUBTYPES AND THEIR MODULATORS
5 ADDITIONAL STRUCTURES
6 RECENT CLINICAL DATA
7 CONCLUSION AND FUTURE PERSPECTIVES
Chapter 4: Medication Development for the Treatment of Substance Abuse
Publisher Summary
1 INTRODUCTION
2 THE ADDICTIVE STATE
3 BEHAVIORAL PHARMACOLOGY MODELS OF ADDICTION
4 PARTIAL AGONIST APPROACH TO MEDICATION DEVELOPMENT
5 OPIOIDS
6 COCAINE
7 STIMULANTS: METHAMPHETAMINE
8 CONCLUSION
Part II: Cardiovascular and Metabolic Diseases
Chapter 5: GPR40 (FFAR1) Modulators
Publisher Summary
1 INTRODUCTION
2 BIOLOGY OF GPR40
3 ARYLPROPIONIC ACIDS
4 LONG CHAIN ALKYL ACID DERIVATIVES
5 ACID ISOSTERES
6 CONCLUSION
Chapter 6: Rho-Kinase Inhibitors for Cardiovascular Disease
Publisher Summary
1 INTRODUCTION
2 PRECLINICAL STUDIES
3 CLINICAL STUDIES
4 STRUCTURE
5 MEDICINAL CHEMISTRY PROGRESS
6 CONCLUSION
7 RECENT DEVELOPMENTS
Chapter 7: LXR Agonists for the Treatment of Atherosclerosis: Recent Highlights
Publisher Summary
1 INTRODUCTION
2 LXR AND ATHEROSCLEROSIS
3 LXR SUBTYPE SELECTIVITY
4 CLINICAL CANDIDATE WAY-252623
5 CONCLUSION
Chapter 8: Glucagon Receptor Antagonists for Type II Diabetes