Animal and Translational Models for CNS Drug Discovery
- Robert McArthur, McArthur & Associates GmbH, Basel, Switzerland
- Franco Borsini, Head, Central & Peripheral Nervous System and General Pharmacology Area - R&D Department, sigma-tau SpA, Pomezia (Rome), Italy
Minimize the number of drug candidates that could later fail in human trials! These three volumes provide a unique examination of how animal models are evolving from ?behavioral gut baths? to providing cross-species information relevant to human clinical responses. Each volume provides the views and experiences of leading pre-clinical and clinical investigators who are actively involved in translational research and experimental medicine.Each volume is devoted to specific disorders in three scientific fields: Psychiatric, Neurological, and Reward Deficit.View full description
Academic neuroscientists involved in the development and use of animal models of neuropsychiatric disorders to study their basic neurobiology; Academic and pharmaceutical neuroscientists involved in the use of animal models of neuropsychiatric disorders to identify and validate novel targets for potential pharmaceutical treatment of these disorders; Clinical and translational neuroscientists concerned with limitations of present neuropsychiatric clinical trial designs, development of valid biomarkers and cross-species; and Pharmaceutical industry, regulatory body and venture capital executives concerned with improvements in the attrition rate of CNS drug candidates.
- Imprint: ACADEMIC PRESS
"These volumes therefore represent the latest, most comprehensive information and perspectives as well as source material for animal models as they relate to issues and concepts in translational medicine." -- James E. Barrett, Drexel University College of Medicine, Philadelphia, PA
Table of ContentsVOLUME 1: Pyschiatric DisordersPreface: What Do You Mean By ?Translational Research?? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Psychiatric DisordersRobert A McArthur and Franco Borsini1. Mark J. Millan. The Discovery and Development of Pharmacotherapy for Psychiatric Disorders: A Critical Survey of Animal and Translational Models, and Perspectives for their Improvement2. L. Winsky et al. Drug Discovery and Development Initiatives at the National Institute of Mental Health: From Cell-Based System to Proof of Concept3. J. McEvoy and Freudenreich. Issues in the Design and Conductance of Clinical Trials4. Klaus A. Miczek. Challenges for Translational Psychopharmacology Research ? The Need for Conceptual Principles5. T. Steckler et al. Developing Novel Anxiolytics: Improving Preclinical Detection and Clinical Assessment6. D. Joel et al. Animal Models of Obsessive-Compulsive Disorder: From Bench to Beside Via Endophenotypes and Biomarkers7. J. Cryan et al. Developing More Efficacious Antidepressant Medications:Improving and Aligning Preclinical and Clinical Assessment Tools8. D. Jones et al. Developing New Drugs for Schizophrenia: From Animals to the Clinic9. C. Large et al. Developing Therapeutics for Bipolar Disorder (BPD): From Animal Models to the Clinic10. R. Tannock et al. Towards a Biological Understanding of ADHD and the Discovery of Novel Therapeutic Approaches11. J. Bartz et al. Preclinical Animal Models of Autistic Spectrum Disorders (ASD)12. S. Doran et al. Translational Models of Sleep and Sleep Disorders Epilogue:Translational Models for the 21st century: Reminiscence, Reflections and Some RecommendationsVOLUME 2: Neurological DisordersPreface: What Do You Mean By ?Translational Research?? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Neurological DisordersRobert A McArthur and Franco Borsini1. A. Jackie Hunter. Animal and Translational Models of Neurological Disorders: An Industrial Perspective2. Lon S Schneider. Issues in Design and Conduct of Clinical Trials for Cognitive-Enhancing Drugs3. C. Shilyansky et al. Molecular And Cellular Mechanisms Of Learning Disabilities: A Focus On Neurofibromatosis Type I4. M. Lindner et al. Development, Optimization and Use of Preclinical Behavioral Models to Maximize the Productivity of Drug Discovery for Alzheimer's Disease5. K. Merchant et al. Animal Models of Parkinson's Disease to Aid Drug Discovery and Development6. T. Wagner et al. Huntington Disease7. J. Montes. Translational Research in ALS8. H. Klitgaard. Animal and Translational Models of the EpilepsiesEpilogue:Translational Models for the 21st century: Reminiscence, Reflections and Some RecommendationsPaul Willner, Franco Borsini, and Robert A McArthurVOLUME 3: Reward Deficit DisordersPreface: What Do You Mean By ?Translational Research?? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Reward Deficit DisordersRobert A McArthur and Franco Borsini1. C. Heidbreder. Impulse and Reward Deficit Disorders: Drug Discovery and Development2. D. McCann et al. Drug Discovery and Development for Reward Disorders: Views from Government3. T. Gardner et al. Issues in Designing and Conduction Clinical Trails for Reward Disorders: A Clinical View4. G. Koob. The Role of Animal Models in Reward Deficit Disorders: Views of Academia5. Hilary J Little et al. Pharmacotherapy of Alcohol Dependence: Improving Translation from the Bench to the Clinic6. A. Markou et al. Contribution of Animal Models and Preclinical Human Studies to Medication: Development for Nicotine Dependence7. B. Rocha et al. Development of Medication for Heroin and Cocaine Addiction and Regulatory Aspects of Abuse Liability Testing8. C. Dourish et al. Anti-obesity Drugs: From Animal Models to Clinical Efficacy9. W. Williams et al. Current Concepts in the Classification, Treatment and Modeling of Pathological Gambling and other Impulse Control DisordersEpilogue:Translational Models for the 21st century: Reminiscence, Reflections and Some RecommendationsPaul Willner, Franco Borsini, and Robert A McArthur