Analytical Determination of Nicotine and Related Compounds and their Metabolites
- J.W. Gorrod, Toxicology Unit, John Tabor Laboratories, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK
- P. Jacob III, The University of California at San Francisco, Division of Clinical Pharmocology, Bldg. 100, Boom 235, 1001 Potrero Avenue, San Francisco, CA 94110, USA
This book provides for the first time a single comprehensive source of information on the analytical chemistry of nicotine and related alkaloids. The editors have brought together scientists from academia and the tobacco industry to describe the state-of-the-art of the chemistry and analytical methods for measurement of nicotine. Both the scope and detail of the book are impressive. Chapters describe the history, pharmacology and toxicology of nicotine, the biosynthesis of nicotine and other alkaloids in the tobacco plant, the general chemistry of nicotine and the analytical methodologies that have been used to measure nicotine and related alkaloids in biological specimens, in tobacco and pharmaceutical products and in tobacco smoke. There is also a comprehensive review of the chemistry and toxicology of nicotine-derived nitrosamines, an important class of tobacco carcinogens.
For tobacco chemists, neuroscientists studying nicotine, clinical researchers, policy makers as well as tobacco and pharmaceutical industry scientists.