Aminopyridines & Similarly Acting Drugs

Effects on Nerves, Muscles and Synapses

Edited by

  • P. Lechat
  • S. Thesleff, University of Lund, Lund, Sweden
  • C. Bowman, University of Strathclyde, Glasgow, UK

Provides a detailed overview of current research into the biological effects of aminopyridines and similarly acting substances. It focuses on their effects on ion channels, and on the modifications of contractility that they produce. The aspects covered range from biophysical studies of basic mechanisms of action to the actual and potential clinical uses in human patients.
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Of interest to physiologists, pharmacologists and, neurobiologists.


Book information

  • Published: April 1982
  • Imprint: PERGAMON
  • ISBN: 978-0-08-028000-4

Table of Contents

(partial) Historical review, P Lechat. General review on potassium currents in excitable membranes of nerve and muscle, H Meves. Effects of aminopyridines on potassium currents of the nodal membrane, W Ulbricht et al. Properties and physiological roles of K+ currents in frog myelinated nerve fibres as revealed by 4-aminopyridine, J M Dubois. Effects of aminopyridines on ionic currents and ionic channel noise in unmyelinated axons, Y Pichon et al. 3- and 4-aminopyridine in synaptic transmission at the squid giant synapse, R Llinas et al. General principles of synaptic transmission, S Thesleff. Effects of aminopyridines on neuromuscular transmission, J Molgo. Effects of 4-aminopyridine on transmission in excitatory and inhibitory synapses in the spinal cord, E Jankowska. The influence of 4-aminopyridine on parasympathetic transmission, F F Foldes et al. Structure activity relationships amongst aminopyridines, I G Marshall. Aminopyridine as a tool to investigate the mechanism of acetylcholine release at the nerve electroplaque junction, Y Dunant. Intramembrane particles changes: a constant feature of the release mechanism, M Israel et al. Effect of aminopyridine and related drugs on catecholamine release, S M Kirpekar et al.