American Trypanosomiasis book cover

American Trypanosomiasis

Chagas Disease One Hundred Years of Research

Chagas disease causes severe socioeconomic impact and a high medical cost in Latin America. WHO and the World Bank consider Chagas disease as the fourth most transmittable disease to have a major impact on public health in Latin America: 120 million persons are potentially exposed, 16 to 18 million of whom are presently infected, causing 45,000 to 50,000 deaths per year. It has been calculated that approximately 2.4 million potential working years are lost because of incapacity and mortality due to the disease, for an annual cost estimated at 20 billion Euros. This book provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease:

  • The host: human and mammalian reservoirs
  • The insect vectors: domestic and sylvatic vectors
  • The causative parasite: Trypanosoma cruzi

Audience
Researchers in parasitology, tropical medicine and public health

Hardbound, 870 Pages

Published: September 2010

Imprint: Elsevier

ISBN: 978-0-12-384876-5

Contents

  • PART I - GENERAL ASPECTS

    1. History of the discovery of the American Trypanosomiasis (Chagas disease)

    Tania Araujo-Jorge, Jenny Telleria, and Jaime Rios Dalenz

    2. Chagas disease in pre-Colombian civilizations

    Felipe Guhl and Arthur Aufderheide

    3. Social and Medical aspects: morbidity and mortality in the general population

    João Carlos Pinto Dias and Christopher John Schofield

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    4. Current trends and future prospects for control of Chagas disease

    Álvaro Moncayo and Antonio Carlos Silveira

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    5. Geographical distribution of Chagas disease

    James S. Patterson and Felipe Guhl

    PART II - INSECT VECTORS

    6. Classification and Phylogeny of the Triatominae

    Maria Dolores Bargues, Chris Schofield and Jean-Pierre Dujardin

    7. Biology of Triatominae

    François Noireau and Jean-Pierre Dujardin

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    8. Population Genetics of Triatomines

    Fernando Monteiro, Paula Marcet and Patricia Dorn

    9. Geographical distribution of Triatominae vectors in America

    David Gorla and François Noireau

    10. Control strategies against Triatominae

    D.E.Gorla, C.Ponce, J-P.Dujardin and C.J.Schofield

    PART III - NON-HUMAN MAMMALIAN HOSTS

    11. Domestic and wild mammalian reservoirs

    Ana Maria Jansen and André Luiz Rodrigues Roque

    12. Veterinary aspects and experimental studies

    Marc Desquesnes and Marta de Lana

    PART IV - THE CAUSATIVE AGENT: TRYPANOSOMA CRUZI

    13. Classification and phylogeny of Trypanosoma cruzi

    Patrick B. Hamilton and Jamie R. Stevens

    14. Biology of Trypanosoma cruzi and biological diversity

    Marta de Lana and Evandro Marques de Menezes Machado

    15. Biochemistry of Trypanosoma cruzi

    Roberto Docampo and Silvia N. J. Moreno

    16. Ultrastructure of Trypanosoma cruzi and its Interaction with Host Cells

    Wanderley de Souza, Tecia Ulisses de Carvalho, Emile Santos Barrias

    17. Genetics of Trypanosoma cruzi

    Sub-chapter: Nuclear genome

    Daniella C. Bartholomeu, Gregory A. Buck, Santuza M. R. Teixeira, Najib M. A. El- Sayed

    Sub-chapter: Kinetoplast genome

    Jenny Telleria, Michal Svoboda

    18. Experimental and Natural recombination in Trypanosoma cruzi

    Michael D. Lewis, Martin S. Llewellyn, Matthew Yeo, Michael A. Miles

    19. Reticulate Evolution in Trypanosoma cruzi: medical and epidemiological implications

    Michel Tibayrenc, Christian Barnabé and Jenny Telleria

    20. Implications of Trypanosoma cruzi intraspecific diversity in the pathogenesis of Chagas Disease

    Andrea Macedo

    PART V - MODES OF TRANSMISSION

    21. Vector transmission

    Simone Frédérique Brenière, Christine Aznar and Mireille Hontebeyrie

    22. Maternal-fetal transmission of Trypanosoma cruzi

    Yves Carlier and Carine Truyens

    23. Other forms of transmission

    Mireille Hontebeyrie, Simone Frédérique Brenière and Christine Aznar

    PART VI - IMMUNOLOGY: HOST-PARASITE INTERACTION

    24. Protective host response to parasite and its limitations

    Carine Truyens and Yves Carlier

    25. Pathological consequences of host response to parasite

    Mireille Hontebeyrie , Carine Truyens and Simone Frédérique Brenière

    26. Human genetic susceptibility to Chagas disease

    Michel Tibayrenc

    PART VII - PATHOLOGY, DIAGNOSIS AND TREATMENT

    27. Clinical phases and forms of Chagas’ disease

    Joffre Marcondes de Rezende, Anis Rassi, Alejandro O. Luquetti and Anis Rassi Junior

    28. Diagnosis of Trypanosoma cruzi infection

    Alejandro O. Luquetti and Gabriel A. Schmuñis

    29. AIDS and Chagas’ disease

    Marcelo Corti, María F. Villafañe

    30. Treatment of Chagas disease

    Werner Apt

    31. Vaccine development for Chagas disease

    Angel Marcelo Padilla, Cecilia Perez Brandan and Miguel Angel Basombrío

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