AID for Immunoglobulin Diversity

Advances in Immunology

Edited by

  • Tasuku Honjo, Kyoto University, Japan

Edited by

  • Frederick Alt, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA

Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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Immunologists and infectious disease specialists, cell biologists and hematologists


Book information

  • Published: June 2007
  • ISBN: 978-0-12-373706-9

Table of Contents

Discovery of Activation-Induced Cytidine Deaminase, the Engraver of Antibody MemoryDNA Deamination in Immunity: Aid in the Context of Its Apobec RelativesThe Role of Activation Induced Deaminase in Antibody Diversification and Chromosome TranslocationsTargeting of AID-mediated Sequence Diversification by cis-acting DeterminantsAID-initiated Purposeful Mutations in Immunoglobulin GenesPost-translational AID Regulation Beyond SHM and CSR: AID and Related Cytidine Deaminases in the Host Response to Viral InfectionAID expression and tumorigenesis Pathophysiology of B Cell Intrinsic Immunoglobulin Class Switch Recombination Deficiencies