Aging of the Brain and Alzheimer's Disease

Edited by

  • D.F. Swaab
  • E. Fliers
  • M. Mirmiran
  • W.A. Van Gool
  • F. Van Haaren

In recent years research on the neurobiological aspects of aging and on Alzheimer's disease has become increasingly important. A number of techniques hitherto applied solely to experimental animals have become available for application on the human brain (e.g. immunocytochemistry, deoxyglucose, mRNA, event-related potentials). The present volume reviews the potential of these powerful techniques for obtaining a better insight into the aging process of the brain, as well as age-related neurodegenerative diseases such as Alzheimer's disease, Huntington's chorea, Parkinson's disease and multi-infarct dementia. Up-to-date information is presented on research from a variety of experimental and clinical disciplines, ranging from neurochemistry and morphology of the aging brain to neuropsychology and neurology. "Aging of the Brain and Alzheimer's Disease" provides an extensive multidisciplinary review on brain research in aging and dementia including diagnosis and therapeutic aspects, and will be of particular interest to neurologists, neuroscientists, pathologists and psychologists working in this field.
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Book information

  • Published: January 1986
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-80793-9

Table of Contents

List of Contributors. Preface. Acknowledgements. 1. Diagnosis. 1. Clinical approach to dementia (H. Van Crevel). 2. Cognitive, emotional and behavioral dysfunctions in aging and dementia (J. Jolles). 3. Interrelations among the lesions of normal and abnormal aging of the brain (R.D. Terry). 4. Age-related changes in Down syndrome brain and the cellular pathology of Alzheimer disease (R.S. Williams and S. Matthysse). 5. Measurement and imaging of cerebral function in ageing and dementia (R.S.J. Frackowiak). 6. The endogenous components of the event-related potential - a diagnostic tool? (E. Donchin et al.). 2. Alterations in the Brain. 7. The current status of the cortical cholinergic system in Alzheimer's disease and Parkinson's disease (J.M. Candy et al.). 8. Monoamines and myelin components in aging and dementia disorders (C.G. Gottfries). 9. Neuropeptide changes in aging and Alzheimer's disease (E. Fliers and D.F. Swaab). 10. Cortical neurochemistry in Alzheimer-type dementia (A.J. Cross et al.). 11. Lipofuscin: characteristics and significance (R.S. Sohal and L.S. Wolfe). 12. Ratio of pyramidal cells versus non-pyramidal cells in the human frontal isocortex and changes in ratio with ageing and Alzheimer's disease (H. Braak and E. Braak). 13. Cationshifts and excitotoxins in Alzheimer and Huntington disease and experimental brain damage (J. Korf et al.). 14. Dendritic proliferation in the aging brain as a compensatory repair mechanism (P.D. Coleman and D.G. Flood). 15. Neuronal cell membranes and brain aging (A.B. Oestreicher et al.). 16. Aging and circadian rhythms (W.A. Van Gool and M. Mirmiran). 17. Neuronal cytoskeleton in aging and dementia (K. Iqbal et al.) 3. Etiological Factors and Animal Models. 18. DNA damage, DNA repair and the genetic basis of Alzheimer's disease (C. Kidson and P. Chen). 19. Transcriptional and translational regulatory mechanisms during normal aging of the mammalian brain and in Alzheimer's disease. (C.A. Marotta et al.). 20. Cell-specific pathology in neural systems of the temporal lobe in Alzheimer's disease (G.W. Van Hoesen et al.). 21. The old animal as a model in research on brain aging and Alzheimer's disease/senile dementia of the Alzheimer type (C.F. Hollander and J. Mos). 22. Behavioral and biochemical effects of nucleus basalis magnocellularis lesions: implications and possible relevance to understanding or treating Alzheimer's disease (R.T. Bartus et al.). 23. Experimental studies on the induction and prevention of retrograde degeneration of basal forebrain cholinergic neurons (M.V. Sofroniew et al.). 24. Scrapie and its association with "amyloid-like" fibrils and glycoproteins encoded by cellular genes: an animal model for human dementia (J. Goudsmit and F.W. Van der Waals). 25. Aluminum: a role in degenerative brain disease associated with neurofibrillary degeneration (D.R. Crapper McLachlan and M.F.A. Van Berkum). 4. Therapeutic Strategies. 26. Clinical strategies in the treatment of Alzheimer's disease (D.F. Swaab and E. Fliers). 27. Neuropeptides and the treatment of cognitive deficits in aging and dementia (J. Jolles). 28. Environmental influences on brain and behavior in aging and Alzheimer's disease (M. Mirmiran et al.). 29. Possible dietary strategies to reduce cognitive deficits in old age (H.R. Lieberman and T.M. Abou-Nader). 30. The striatal dopaminergic system as a model for modulation of altered neurotransmitter action during aging: effects of dietary and neuroendocrine manipulations (G.S. Roth et al.). 31. Muscarinic cholinergic agonists: pharmacological and clinical perspectives (J. M. Palacios and R. Spiegel). 32. Transplantation of basal forebrain cholinergic neurons in the aged rat brain (A. Björklund and F.H. Gage). Subject Index.