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The first review series in virology and published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the field.… Read more
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The first review series in virology and published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the field.
Professional virologists, from professors to graduate students, microbiologists and infectious diseases specialists.
Contributors
Chapter One. Revisiting Dengue Virus–Host Cell Interaction: New Insights into Molecular and Cellular Virology
Abstract
1 Introduction
2 Dengue Disease
3 The Molecular Biology of DENV
4 The DENV–Host Cell Interface: High-Throughput Approaches to Identify Relevant Host Cell Factors and Pathways
5 Host Dependency Factors and Their Role in the DENV Replication Cycle
6 Host Restriction Factors and Their Role in the DENV Replication Cycle
7 Host Cell Factors as Target for Antiviral Agents
8 Concluding Remarks
Acknowledgments
References
Chapter Two. KSHV: Pathways to Tumorigenesis and Persistent Infection
Abstract
1 Malignancies and Syndromes Linked with KSHV Infection
2 KSHV Biology: Virion, Transmission, and Viral Lifecycle
3 Lytic KSHV Proteins Involved in Cell Growth and Survival
4 KSHV's Activation and Evasion of the Host Immune Response
5 Conclusions
Acknowledgments
References
Chapter Three. Evolution and Emergence of Plant Viruses
Abstract
1 Introduction
2 Phase I: Virus Encounter of New Hosts or New Conditions
3 Phase II: Virus Adaptation to a New Host or New Conditions
4 Phase III: Long-Term Changes in Virus Epidemiology
5 Conclusions: Gaps in Understanding Plant Virus Emergence
Acknowledgments
References
Chapter Four. Quantitative Genetics in the Study of Virus-Induced Disease
Abstract
1 Background
2 Approaches to Genetic Mapping
3 Genetic Mapping of Viral Disease Related Genes Within the Human Population
4 Experimental Approaches to Studying Host Genetic Influences on Viral Diseases
5 The Collaborative Cross as an Integrative Genetic Mapping and Systems Biology Platform
6 Looking Forward
Acknowledgments
References
Chapter Five. Bacteriophages of Pseudomonas aeruginosa: Long-Term Prospects for Use in Phage Therapy
Abstract
1 Introduction
2 Conditions Predisposing to P. aeruginosa Infection. Phage Therapy in Treatment of P. aeruginosa Infections: General Approach
3 Classification and Safety Certification of Phages for Therapy
4 Phage Potential of P. aeruginosa: Significance of Genetic Interactions in Course of Possible Migrations of Phages
5 Selection of the Most Active Phages to Compose Mixtures. Expansion of the Number of Available Therapeutic Phages for P. aeruginosa
6 P. aeruginosa Bacteriophages and CF
7 Future Studies and Organizational Procedures to Support Long-Term Use of P. aeruginosa Phages in Therapy
Acknowledgments
References
Chapter Six. Dynamic Epstein–Barr Virus Gene Expression on the Path to B-Cell Transformation
Abstract
1 Background
2 Virion-Associated RNAs and Very Early Events in Infection
3 Viral Gene Expression During the Prelatent Phase Early After Infection
4 miRNAs and Other Noncoding RNAs Involved in Transformation
5 Dynamic Control of Viral Promoters Leads to Specificity of Latent Gene Expression
6 Delayed Expression of LMP1 Ultimately Required for Transformation
7 Heterogeneity in Steady-State EBV Gene Expression in LCLs
8 Conclusions and Future Directions
Acknowledgments
References
Chapter Seven. Dengue Virus Vaccine Development
Abstract
1 Virology and Epidemiology of DENV Infection
2 Adaptive Immune Response to DENV
3 Dengue Vaccine Objectives and Challenges
4 Animal Models for Testing Dengue Vaccine Candidates
5 Dengue Vaccine Approaches
6 DNA Vaccines
7 Viral Vectored Vaccines
8 Inactivated Whole Virus
9 Live Attenuated
10 Moving Forward
References
Index
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