Contents. List of Contributors. Introduction to Volume 5 (S.L. Bonting). Exemsi: The Second European Simulation of a Long-Duration Mannes Space Mission (J. Collet and R.J. Vaernes). Exemsi: Description of Facilities, Organization, Crew Selection, and Operational Aspects (R.J. Vaernes). Body Weight and Body Composition during Sixty Days of Isolation (H.Chr. Gunga, K.A. Kirsch, L. Rocker, A. Maillet, and C. Gharib). Hormonal, Water Balance, and Electrolyte Changes during Sixty-Day Confinement (A. Maillet, S. Normand, H.C. Gunga, A.M. Allevard, J.M. Cottet-ERnard, E. Kihm, F. Strollo, C. Pachiaudi, K.A. Kirsch, C.A. Bizollon, G. Gauquelin, and C. Gharib). Food Intake and Nutritional Status during Exemsi (H. Milon, B. Decardi, A. Adine, and E. Kihm). Neuroendocrine System and Immune Responses after Confinement (D. Husson, M. Abbal, M. Tafani, and D.A. Schmitt). Local Immunocompetence and Salivary Cortisol in Confinement (J. Hennig and P. Netter). Cardiovascular and Respiratory Responses during a Complex Decision-Making Task under Prolonged Isolation (C.J.E. Wientjes, J.A. Veltman, and A.W.K. Gaillard). Performance and Brain Electrical Activity during Prolonged Confinement (B. Lorenz, J. Lorenz, and D. Manzey). Attention and Mental Performance in Confinement: Evidence from Cognitive Psychophysiology (A. Mecklinger, A.D. Friederici, and T. Gussow). Simulations of Circadian System and Vigilance during Space Missions (P. Achermann and A.A. Borbely). Crew Compatibility and Interaction (G.M. Sandal, R. Vaernes, and H. Ursin). Group Dynamics and Crew Interaction during Isolation (K.N. Eskov, M.A. Novikov, A.G. Viknokhodova, and V.N. Bricksin). Group Dynamics during the Exemsi Isolation Study (C. Cazes, E. Rosnet, C. Bachelard, C. Le Scanff, and J. Rivolier). Ethological Analysis of Crew Member Behavior: Distances, Orientations, and Postures (C. Tafforin). Psychological Evaluation and Support during Exemsi (V.I. GUshin, T.B. Kolinitchenko, V.A. Efimov, and C. Davies). Work Capability during Isolation (V.I. Gushin, V.A. Efimov, and T.M. Smirnova). Cognitive Fatigue and Complex Decision making under Prolonged Isolation and Confinement (G.R.J. Hockey and J. Sauer). Similarities between Sustained Sport Performance and Behavior in Extended Spaceflights (G. Gillot, N. Kane-Toure, and S. Mahiddine). Bioregeneration in Space (L. Wolf). Operational Evaluation of the Exemsi Project (J.R. Kass, F. Ellmers, and J. Schiemann). Lessons learned from Isemsi and Exemsi (R.J. Vaernes). Index.