Advances in Protein Chemistry and Structural Biology book cover

Advances in Protein Chemistry and Structural Biology

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Hardbound, 296 Pages

Published: December 2010

Imprint: Academic Press

ISBN: 978-0-12-381264-3


    1. Proteomics technologies for the global identification and quantification of proteins
    2. Ian A. Brewis and P. Brennan

    3. Targeted metabolomics and mass spectrometry
    4. E. Dudley, M. Yousef, Y. Wang, W.J. Griffiths

    5. Mechanisms of Protein Circular Dichroism: Insights from Computational Modelling
    6. Tatyana Karabencheva and Christo Christov

    7. Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling
    8. Jonathan G. L. Mullins, Seo-Kyung Chung and Mark I. Rees

    9. Positive and Negative Modulation of Nicotinic Receptors
    10. Hugo R. Arias

    11. Sonochemically Born Proteinaceous Micro- and Nanocapsules

    Elena D. Vassileva and Neli S. Koseva


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