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Advances in Molecular Toxicology
1st Edition, Volume 8 - September 30, 2014
Editors: James C. Fishbein, Jacqueline M. Heilman
Language: English
Hardback ISBN:9780444634061
9 7 8 - 0 - 4 4 4 - 6 3 4 0 6 - 1
eBook ISBN:9780444633903
9 7 8 - 0 - 4 4 4 - 6 3 3 9 0 - 3
Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this…Read more
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Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field.
Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed.
Cutting-edge reviews by leading workers in the discipline
In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines
Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine
For academics in the field of chemistry, biochemistry, toxicology, pharmacology medicine; for Government agencies and those in industry, pharmaceutical and chemical manufacturers
Preface
Chapter One: The Mechanistic Complexities of Phycotoxins: Toxicology of Azaspiracids and Yessotoxins
Abstract
1 Introduction
2 Azaspiracids
3 Yessotoxins
Acknowledgments
Chapter Two: Advances in the Analysis of Challenging Food Contaminants: Nanoparticles, Bisphenols, Mycotoxins, and Brominated Flame Retardants
Abstract
1 Introduction
2 Analytical Methodology for the Analysis of Nanoparticles
3 Analytical Methodology for the Analysis of Bisphenols
4 Analytical Methodology for the Analysis of Mycotoxins
5 Analytical Methodology for the Analysis of BFRs
6 Conclusions
Acknowledgments
Chapter Three: Mycotoxins from Alternaria: Toxicological Implications
Abstract
1 Introduction
2 Chemical Structures
3 Acute Toxicity
4 Toxicokinetics and Metabolism
5 Genotoxicity and Related Mechanism
6 Estrogenic Activity and Related Mechanisms
7 Mutagenicity and Carcinogenicity
8 Gastrointestinal Stability of AOH and ALT Under In Vitro Human Conditions
9 Conclusions and Outlook
Chapter Four: Food-Borne Topoisomerase Inhibitors: Risk or Benefit
Abstract
1 Introduction
2 Catalytic Enzyme Cycle
3 Drug–DNA Interaction: “Inhibitor Versus Poison”
4 Topoisomerase Inhibitors in Cancer Therapy
5 Secondary Plant Constituents as Topoisomerase Inhibitors
6 Conclusion
Acknowledgments
Chapter Five: Toxicity of Plasmonic Nanomaterials and Their Hybrid Nanocomposites
Abstract
1 Introduction
2 Toxicity Testing and Risk Assessment of Nanomaterials
3 Toxicity Evaluation
4 Animal Testing for Toxicity
5 Factors Affecting Nanotoxicology
6 Genotoxicology
7 The Most Common Genotoxicological Tests
8 Genotoxicity of Plasmonic Nanomaterials
9 Evaluation of Genotoxicity of Magneto-Plasmonic Hybrid Nanocomposites
10 Conclusion
Chapter Six: Aluminum Phytotoxicity: Physiological Approaches and Tolerance
Abstract
1 General Considerations
2 Aluminum and Plants’ Responses
3 Aluminum and the Apoplast–Symplast Continuum
4 Aluminum and Oxidative Stress
5 Aluminum and Callose Deposition
6 Aluminum and Photosynthesis
7 Aluminum Tolerance
8 Final Remarks
Acknowledgments
Index
No. of pages: 278
Language: English
Edition: 1
Volume: 8
Published: September 30, 2014
Imprint: Elsevier
Hardback ISBN: 9780444634061
eBook ISBN: 9780444633903
JF
James C. Fishbein
Dr. James Fishbein works at the Department of Chemistry and Biochemistry, University of Maryland.
Affiliations and expertise
Department of Chemistry and Biochemistry, University of Maryland, Baltimore, MD, USA
JH
Jacqueline M. Heilman
Dr. Jacqueline Heilman works at Exponent, Inc., Washington, DC, USA
Affiliations and expertise
Exponent, Inc., Washington, DC, USA
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