Advances in Medicinal Chemistry, Volume 5
- A.B. Reitz, Drug Discovery, R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USA
- S.L. Dax, Drug Discovery, R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USA
Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.
For students, researchers and industrialists in the field of medicinal chemistry.