Advances in Enzyme Regulation

Proceedings of the Forty-Fifth International Symposium

Edited by

  • George Weber, Indiana University School of Medicine, Indianapolis, USA

Volume 45 of Advances in Enzyme Regulation is the proceedings of the 45th International Synthesis in Normal and Neoplastic Tissues held at Indiana University School of Medicine Indianapolis, Indiana September 27-28, 2004.Volume 45 concentrates on subjects which have reached the stage of productive summarizaiton and critical evaluation in the light of extensive new results. This book also lives up to its goal of advancing a few steps ahead of the general front of mammalian enzymic and metabolic regulation studies.
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Biochemists, biophysicists, cell biologists, molecular biologists, geneticists, developmental biologists


Book information

  • Published: December 2005
  • Imprint: ELSEVIER
  • ISBN: 978-0-08-044738-4

Table of Contents

AcknowledgmentsList of participantsSESSION I NUCLEAR CONTROLImplications for Nuclear Organization and Gene Transcription of Lamin A/C Specific Mutations.Spatio-Temporal Dynamics of Genomic Organization and Function in the Mammalian Cell NucleusSESSION II METABOLIC DESIGN AND REGULATIONMetabolic Design Principles: Chemical and Physical Determinants of Cell Chemistry.Down-regulation of Increased Signal Transduction in Human Cancer Cells.SESSION III RAS AND REGULATIONRas Initiates Phosphatidyl-Inositol-3-Kinase(P13K)/PKB Mediated Signalling Pathways in Untransformed Human Peripheral Blood T Lymphocytes.Functional Analysis and Secondary Espression Profiling of Candidate Genes Deregulated in Conjunction with Oncogenic Ras SignalingSESSION IV CONTROLS AND APOPTOSISInduction of Apoptosis in p53-Deficient L1210 Cells by an I KAPPA Beta Alpha Inhibitor (Bay 11-7085) via a NF KAPPA-Beta-Independent Mechanism.Regulation of Gene and Protein Expression in Cardiac Myocyte Hypertrophy and Apoptosis.SESSION V REGULATION OF KEY ENZYMESPeptide Inhibitors of Mammalian Ribonucleotide Reductase.SESSION VI NUCLEAR FUNCTION AND HUMAN NEOPLASIANuclear Phospholipase C Beta1, Regulation of the Cell Cycle and Progression of Acute Myeloid Leukemia.Combinatorial Organization of the Transcriptional Regulatory Machinery in Biological Control and Cancer.SESSION VII EVOLUTIONARY CONSERVED SIGNAL PATHWAYSPhosphatidylinositol Transfer Protein Function in the Yeast Saccharomyces cerevisiae.Modification of Protein Sub-Nuclear Location by Synthetic Phosphoinositides: Evidence for Nuclear Phosphoinositide Signaling Mechamisms.SESSION VIII SIGNAL TRANSDUCTION AND STRUCTURAL IMPACTRole of Signal Transduction and Actin in G1 Phase Progression.Emerging Roles of Phosphatidylinositol Monophosphates in Cellular Signaling and Trafficking.SESSION IX SIGNAL TRANSDUCTIONHuman Guanylate Binding Protein-1 (hGBP-1) Characterizes and Establishes a Non-Angiogenic Endothelial Cell Activation Phenotype in Inflammatory Diseases.SESSION X SPECIAL SYMPOSIUM LECTURE: H.L. PEARCEThe Evolution of Cancer Research and Drug Discovery at Lilly Research Laboratories.