Advances in DNA Sequence-specific Agents, Volume 1Edited by
- L.H. Hurley
For scientists and researchers in the field of DNA sequenencing.
Advances in DNA Sequence-Specific Agents
Published: June 1992
- List of Contributors. Introduction to the series: an editor's foreword (A. Padwa). Preface (L.H. Hurley).Part I: Methods used to evaluate sequence specificity of DNA reactive compounds.Application of equilibrium binding methods to elucidate the sequence specificity of antibiotic binding to DNA (J.B. Chaires). Quantitative aspects of DNASE 1+ footprinting (J.Goodisman, J.C. Dabrowiak). Use of circular dichroism to probe DNA structure and drug binding to DNA (C. Zimmer, G. Luck). NMR analysis of reversible nucleic acid-small molecule complexes (W.D. Wilson et al.). Use of enzymatic and chemical probes to determine the effect of drug binding on local DNA structure (K.R. Fox).Part II: Sequence specificity of drugs that interact with DNA in the minor groove.The DNA sequence selectivity of CC-1065 (M.A. Warpehoski). Mitomycin C: DNA sequence specificity of a natural DNA cross-linking agent (M. Tomasz). Sequence specificity of the pyrrolo(1,4)benzodiazepines (J.A. Mountzouris, L.H. Hurley). Calicheamicin/esperamicin (G. Ellestad et al.). DNA sequence controls mechanism of oxidative deoxyribose damage by neocarzinostatin (I.H. Goldberg). Index.