Save up to 30% on Elsevier print and eBooks with free shipping. No promo code needed.
Save up to 30% on print and eBooks.
Advances in Clinical Chemistry
1st Edition, Volume 67 - November 20, 2014
Editor: Gregory S. Makowski
Language: English
Hardback ISBN:9780128022672
9 7 8 - 0 - 1 2 - 8 0 2 2 6 7 - 2
eBook ISBN:9780128024669
9 7 8 - 0 - 1 2 - 8 0 2 4 6 6 - 9
Volume 67 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research…Read more
Purchase options
LIMITED OFFER
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
Volume 67 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.
Expertise of international contributors
Latest cutting-edge technologies
Comprehensive in scope
Clinical Laboratory Professionals, Physicians and Research Scientists
Preface
Chapter One: Biomarkers of Tobacco Smoke Exposure
Abstract
1 Introduction
2 Definitions
3 Types of Biomarkers
4 Biomarkers of Smoking Versus Biomarkers of Biological State
5 From Smoke to Disease: Genomics and Novel Molecular Pathways
6 Modulating Factors
7 Biomarker Uses
8 Validation and Qualification
9 Conclusions
Disclaimer
Chapter Two: Ethyl Glucuronide and Ethyl Sulfate
Abstract
1 Introduction
2 Metabolism of Alcohol
3 Stability
4 Cutoff Values
5 Detection Times
6 Methods for Measurement of EtG and EtS
7 Applications
8 Confounders Causing False-Positive or False-Negative Results
9 Conclusions
Declarations
Chapter Three: Ammonia Metabolism and Hyperammonemic Disorders
Abstract
1 Introduction
2 Solubility of Ammonia and Transport Across Cell Membranes
3 Sources of Ammonia
4 Disposal of Ammonia
5 Ammonia Metabolism in Liver
6 Ammonia Metabolism in Brain
7 Ammonia and Arginine Production in the Kidneys
8 Toxicity of Ammonia
9 The Pathogenesis of Hyperammonemic Encephalopathy
10 Clinical Disorders with HA: Overview
11 Inherited Hyperammonemic Disorders
12 Liver Disease
13 Sodium Valproate
14 Urinary Tract Disorders
15 Miscellaneous Causes
16 Conclusions
Chapter Four: 5-Methylcytosine and Its Derivatives
Abstract
1 Introduction
2 Global Detection of 5-mC and Its Oxidation Derivatives
3 Location Analysis of 5-mC and Its Derivatives
4 Conclusions and Perspectives
Acknowledgments
Chapter Five: Circulating microRNAs as Promising Tumor Biomarkers
Abstract
1 Introduction
2 miRNA Biogenesis
3 miRNAs and Cancer
4 Origin and Function of Circulating miRNAs
5 Detection of Circulating miRNAs
6 Circulating miRNAs as Cancer Biomarkers
7 Conclusions
Chapter Six: Proteomics in Transplantation
Abstract
1 Introduction
2 History
3 Sample Sources
4 Proteomic Technology
5 Proteomic Studies
6 Future Aspects, Quo Vadis?
Chapter Seven: Fibulins and Their Role in Cardiovascular Biology and Disease
Abstract
1 Introduction
2 Genes, Expression and Biochemistry
3 Genetically Modified Animals
4 Expression of Fibulins in Heart and Vasculature During Development
5 Fibulins in Arterial Disease
6 Fibulins and Heart Disease
7 Circulating Fibulins
8 Fibulins and Hemostasis
9 Fibulins and Possible Mechanism of Regulation
10 Conclusions and Perspectives
Index
No. of pages: 284
Language: English
Edition: 1
Volume: 67
Published: November 20, 2014
Imprint: Academic Press
Hardback ISBN: 9780128022672
eBook ISBN: 9780128024669
GM
Gregory S. Makowski
Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.
Affiliations and expertise
Vice President and Chief Scientific Officer, Clinical Laboratory Partners, Newington, CT, USA
Read Advances in Clinical Chemistry on ScienceDirect