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Advances in Clinical Chemistry
1st Edition, Volume 63 - December 19, 2013
Editor: Gregory S. Makowski
Language: English
Hardback ISBN:9780128000946
9 7 8 - 0 - 1 2 - 8 0 0 0 9 4 - 6
eBook ISBN:9780128003565
9 7 8 - 0 - 1 2 - 8 0 0 3 5 6 - 5
Volume 63 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research…Read more
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Volume 63 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.
Expertise of international contributors
Latest cutting-edge technologies
Comprehensive in scope
Clinical Laboratory Professionals, Physicians and Research Scientists
Contributors
Preface
Chapter One. Vitamin D Binding Protein: A Multifunctional Protein of Clinical Importance
Abstract
1 Introduction
2 Identification of DBP Polymorphisms and Its Geographical Distribution
3 Analytical Issues
4 The Multifunctional Character of DBP (Fig. 1.3)
5 Clinical Importance of DBP in Cancer (Table 1.1A)
6 Clinical Importance of DBP in Noncancer-Related Diseases (Table 1.1B)
7 DBP as a Therapeutic Agent
References
Chapter Two. Free Testosterone: Clinical Utility and Important Analytical Aspects of Measurement
Abstract
Abbreviations
1 Androgen Physiology
2 Clinical Utility of Measuring Testosterone
3 Laboratory Methods for Measuring Free and BAT
4 Conclusions
References
Chapter Three. Urine Retinol-Binding Protein 4: A Functional Biomarker of the Proximal Renal Tubule
Abstract
1 Introduction
2 Nomenclature
3 History
4 Molecular Structure, Interactions, and Transport of Plasma RBP4
5 Renal Handling of RBP4 and Other Plasma Proteins
6 RBP4 in Plasma and Urine Excretion
7 uRBP4 Assay
8 Stability of uRBP4
9 Clinical Application of uRBP4 Measurement
10 Toxicology and Drug Effects
11 HIV Disease
12 Summary
13 Executive Summary
References
Chapter Four. Proteomics for Breast Cancer Urine Biomarkers
Abstract
Abbreviations
1 Introduction
2 Current BC Biomarker Studies Using Proteomics
3 Urine as a Potential Source for Biomarkers
4 Potential Urine Biomarkers Identified Using Proteomic Techniques in BC
5 Key Proteomic Techniques in Urine Biomarker Research
6 Conclusions and Future Directions
Acknowledgments
References
Chapter Five. Pregnancy-Associated Plasma Protein A (PAPP-A) and Preeclampsia
Abstract
Abbreviations
1 Preeclampsia—Basic Information and Markers
2 PAPP-A and the Current State of the Art
3 Measuring the Concentration of PAPP-A
4 PAPP-A in Pregnancy
5 PAPP-A as a Marker of Other Diseases
6 Conclusion
Acknowledgments
References
Chapter Six. Pediatric Hypoglycemia
Abstract
1 Definition of Hypoglycemia
2 Short- and Long-Term Consequences
3 Transition from Fetal to Neonatal Glucose Homeostasis
4 Monitoring of Neonatal Hypoglycemia and At-Risk Groups
5 Biochemistry of Hypoglycemia
6 Idiopathic Ketotic Hypoglycemia
7 Drug-Related Hypoglycemia
8 Point-of-Care Testing for Hypoglycemia
9 Laboratory Investigation of Hypoglycemia
10 Conclusion
References
Chapter Seven. Paraoxonases and Chemokine (C–C Motif) Ligand-2 in Noncommunicable Diseases
Abstract
1 Obesity in Noncommunicable Diseases
2 Paraoxonases and Regulation of Oxidative Stress
3 Chemokine Superfamily: Migration of Immune Cells In Vivo
4 Chronic Liver Diseases: Oxidative Stress and Inflammation
5 Measurement of PON Enzymes and CCL2
6 Conclusion
Acknowledgments
References
Index
No. of pages: 332
Language: English
Edition: 1
Volume: 63
Published: December 19, 2013
Imprint: Academic Press
Hardback ISBN: 9780128000946
eBook ISBN: 9780128003565
GM
Gregory S. Makowski
Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.
Affiliations and expertise
Vice President and Chief Scientific Officer, Clinical Laboratory Partners, Newington, CT, USA
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