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Advances in Clinical Chemistry
1st Edition, Volume 54 - April 22, 2011
Editor: Gregory S. Makowski
Language: English
Hardback ISBN:9780123870254
9 7 8 - 0 - 1 2 - 3 8 7 0 2 5 - 4
eBook ISBN:9780123870261
9 7 8 - 0 - 1 2 - 3 8 7 0 2 6 - 1
Volume 54 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors a…Read more
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Volume 54 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology.
Leading experts from academia and clinical laboratory science
Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies
Biochemists and clinical biochemists
Preface
Heat-shock proteins in cardiovascular disease
Abbreviations
2. Introduction
3. Atherogenesis and Possible Stimuli of Inducible HSPs
4. HSPs/Anti-HSPs as Biomarkers of Atherothrombosis
5. Molecular Mechanisms: Bystanders or Actors?
6. HSP as Therapeutic Targets in CVD/Atherothrombosis
7. Conclusions
Acknowledgments
Polyamines in cancer
Abbreviations
2. Introduction
3. Overview of Polyamine Regulation
4. Deregulation of Polyamines in Cancer
5. Genetic Variability in ODC Affecting Carcinogenesis
6. EIF5A and Cancer
7. Chemoprevention Strategies Within Polyamine Pathway
Acknowledgments
Acquired hemophilia A
2. Introduction
3. Pathogenesis
4. Laboratory Diagnosis
5. Conclusions
Acknowledgments
Hypobetalipoproteinemia
Abbreviations
2. Introduction
3. Pathways of apoB-Containing Lipoproteins Production
4. Dominant Forms of Primary HBL
5. Recessive Forms of Primary HBL
6. Primary Orphan FHBL
7. Spectrum of Clinical Manifestations in Primary HBL
8. Main Clinical Issues of FHBL
9. Secondary Hypobetalipoproteinemias
10. Conclusions
Addendum
Acknowledgment
Sm peptides in differentiation of autoimmune diseases
2. Introduction
3. Systemic Lupus Erythematosus
4. Mixed Connective Tissue Disease
5. Biochemical Aspects of the Sm Antigen
6. Characteristics of Anti-Sm Antibodies
7. Detection of Anti-Sm Antibodies
8. Clinical Association of Anti-Sm Antibodies
9. Meta-Analysis of Anti-Sm Antibodies
10. Genesis of Anti-Sm Antibodies
11. (Sm) Peptides as Antigens
12. Summary and Conclusion
13. Take Home Messages
Aromatase activity and bone loss
2. Introduction
3. Aromatase and Sources of Estrogen Production
4. The Aromatase Gene and Its Tissue-Specific Regulation
5. Aromatase Deficiency and the Bone
6. Skeletal Consequences of Aromatase Excess
7. Threshold Estradiol Hypothesis for Skeletal Sufficiency
8. Variability in the Level of Aromatase Activity: Effects on Bone Metabolism
9. Summary and Conclusions
Biochemistry of adolescent idiopathic scoliosis
2. Introduction
3. Bone Biochemical Parameters
4. Hormones
5. Trace Elements
6. Hematological Parameters—Platelets
7. Melatonin
8. Conclusions
No. of pages: 204
Language: English
Edition: 1
Volume: 54
Published: April 22, 2011
Imprint: Academic Press
Hardback ISBN: 9780123870254
eBook ISBN: 9780123870261
GM
Gregory S. Makowski
Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.
Affiliations and expertise
Vice President and Chief Scientific Officer, Clinical Laboratory Partners, Newington, CT, USA
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