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Advances in Cancer Research
1st Edition, Volume 98 - April 3, 2007
Editors: George F. Vande Woude, George Klein
Language: English
Hardback ISBN:9780123738967
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eBook ISBN:9780080488141
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The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. A very special event the Nobel Minisy…Read more
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The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. A very special event the Nobel Minisymposium, “Molecular Oncology – From Bench to Bedside,” held at the Karolinska Instituet, in Stockholm, Sweden, was marked the celebration of George and Eva Klein’s combined 160th birthday. To honor this occasion, this 2nd of two volumes brings together contributions by their former students, colleagues and collaborators of the past fifty years into a volume of Advances in Cancer Research dedicated to George and Eva. Over a decade ago, a subdivision of ACR called “Foundations in Cancer Research” was initiated and the tributes honoring the Kleins’ bodies of work presented at the minisymposium are especially appropriate for the series.
Researchers and students in the basic and clinical science of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology and molecular biology.
Contributors
Publisher Summary
Why Do We Not All Die of Cancer at an Early Age?
Abstract
I Introduction
II Immune Surveillance
III Genetic Surveillance (DNA Repair)
IV Intracellular Surveillance
V Is There Epigenetic Surveillance?
VI Intercellular Surveillance
VII Summary
Acknowledgments
The Early History of Plasma Cell Tumors in Mice, 1954–1976†
Abstract
I Introduction
II Plasma Cells Before the 1950s: Discovery, Uncertain Origins
III Multiple Myeloma
IV Abnormal Protein
V New Ideas About the Cellular Basis of Antibody Formation in the 1950s
VI First PCTs in Mice
VII Lloyd Law’s Suggestion
VIII X5563 and X5647
IX Specific Induction of PCTs in Mice by Implanting Millipore Diffusion Chambers: Ruth Merwin and Thelma Dunn
X Mineral Oil and the Hyperimmunization Hypothesis
XI Discoveries on Antibody Structure Using Human Myeloma Proteins Changed the Course of Immunology, 1961–1965
XII Enter Mel Cohn
XIII Pneumococcal Type C Polysaccharide (PnC) and Phosphorylcholine
XIV Herman Eisen, DNP, and MOPC315
XV Irrelevant and Relevant Antigens
XVI The Antidextrans, Antilevans, and Antigalactans
XVII Growing PCTs in Culture and Growth Factors
Acknowledgments
Mouse Mammary Tumor Biology: A Short History
Abstract
I Introduction
II The Dawning of Experimental Cancer Research
III Mendelian Mouse Genetics: 1909–1920
IV The Inbred Mouse in Mouse Mammary Tumorigenesis: 1920–19303
V The Extrachromosomal Factor: 1933–1940
VI The Milk Agent 1936–1970
VII MMTV and the Rise of Tumor Immunology
VIII Hormones and the Emergence of Endocrinology
IX The National Cancer Institute and the Birth of Molecular Biology: 1970–1980
X Neoplastic Progression: 1954
XI Neoplastic Progression: 1959 the HAN
XII Genetically Engineered Mice: 1984–2006
XIII Epilog
Acknowledgments
Ordered Heterogeneity and Its Decline in Cancer and Aging
Abstract
I Introduction
II The Role of Tissue Size in Developmental Biology
III Behavior of Dissociated Cells and Their Reassociation
IV The Molecular Basis of Cell–Cell Adhesion
V Contact Relations Among Homophilic Cells in Regulation of Growth and Proliferation
VI Role of the Plasma Membrane in the Regulation of Cell Growth
VII Normalization of Neoplastic Cells by Contact with Normal Cells
VIII Concluding Remarks
Acknowledgments
Reversal of Tumor Resistance to Apoptotic Stimuli by Alteration of Membrane Fluidity: Therapeutic Implications
Abstract
I Introduction
II Membrane Structure and Dynamics
III Involvement of Physicochemical Properties of the Plasma Membrane in Cellular Functions of Normal and Tumor Cells
IV Membrane Fluidity and Apoptosis
V Membrane Fluidity and Cancer
VI Membrane Fluidity in Cancer Therapy
VII Modulation of Multidrug Resistance by Alterations of Membrane Fluidity
VIII Therapeutic Interventions and Novel Approaches in Cancer Therapy
IX Concluding Remarks
Acknowledgments
Mutant Transcription Factors and Tyrosine Kinases as Therapeutic Targets for Leukemias: From Acute Promyelocytic Leukemia to Chronic Myeloid Leukemia and Beyond
Abstract
I Introduction
II PML‐RARα as a Therapeutic Target for Differentiation Therapy
III Tyrosine Kinases as Target for Apoptosis Induction Therapy
IV Perspectives
Acknowledgments
The Effect of Cell–Matrix Interactions and Aging on the Malignant Process
Abstract
I Introduction
II The Extracellular Matrix
III Age‐Dependent Changes of Tissues
IV Cell–Matrix Interactions
V Role of Proteolytic Enzymes and ROS
VI The Elastin‐Laminin Receptor
VII Modifications of ECM‐Patterning by the Neoplastic Process
VIII Role of ECM Macromolecules
IX Effect of Cell‐Aging and of Modified Cell–Matrix Interactions on the Malignant Process
X Signaling by ECM Macromolecules and Their Proteolytic Fragments
XI Concluding Remarks
Note Added in Proof
Acknowledgments
Index
Publisher Summary
No. of pages: 280
Language: English
Edition: 1
Volume: 98
Published: April 3, 2007
Imprint: Academic Press
Hardback ISBN: 9780123738967
eBook ISBN: 9780080488141
GV
George F. Vande Woude
Affiliations and expertise
Director, Van Andel Research Institute, Grand Rapids, MI, USA
NCI-Frederick Cancer Research Facility Frederick, Maryland
ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland