Accurate Results in the Clinical Laboratory
A Guide to Error Detection and Correction
Edited by- Amitava Dasgupta, Professor, Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston, TX, USA
- Jorge Sepulveda, MD, PhD, Associate Professor and Associate Director of Laboratory Medicine, Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA
This practical, easy-to-use guide addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care.
Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management.
Hardbound, 382 Pages
Published: February 2013
Imprint: Elsevier
ISBN: 978-0-12-415783-5
Contents
Chapter 1. Variation, Errors, and Quality in the Clinical Laboratory
Jorge Sepulveda
Chapter 2. Effect of Age, Gender, Diet, Exercise and Ethnicity on Laboratory Test Results
Octavia M. Peck Palmer
Chapter 3. Effect of patient preparation, specimen collection, anticoagulants and preservatives on laboratory tests
Leland Baskin, Valerian Dias, Alex Chin, Amid Abdullah and Christopher Naugler
Chapter 4. Sample processing and specimen misidentification issues
Alison Woodworth and Amy L. Pyle
Chapter 5. Hemolysis, lipemia and high bilirubin: effect on laboratory tests
Steven C. Kazmierczak
Chapter 6. Immunoassay design and mechanism of interferences
Pradip Datta
Chapter 7. Effect of herbal remedies on clinical laboratory tests
Amitava Dasgupta
Chapter 8. Challenges in routine clinical chemistry: analysis of small molecules
Jorge Sepulveda
Chapter 9. Challenges in routine clinical chemistry: proteins and enzymes
Jorge Sepulveda
Chapter 10. Sources of inaccuracy in biochemical genetics analysis
Michael J. Bennett
Chapter 11. Challenges in endocrinology testingLindsay A. L. Bazydlo, Neil S. Harris and William E. Winter
Chapter 12. Pitfalls in tumor marker testingAlyaa Al-Ibraheemi, Amitava Dasgupta, and Amer Wahed, M.D
Chapter 13. Issues of interferences in therapeutic drug monitoringGwendolyn A. McMillin, and Kamisha L. Johnson-Davis
Chapter 14. Limitations of drugs of abuse testingAmitava Dasgupta
Chapter 15. Challenges in confirmation testing for drugs of abuseLarry A. Broussard
Chapter 16. Alcohol determination using automated analyzers: limitations and pitfallsSheila Dawling
Chapter 17. Pre-analytical issues and interferences in transfusion medicine testsElena Nedelcu
Chapter 18. Critical issues in immunology and serology testingAmer Wahed, Semyon Risin
Chapter 19. Sources of errors in hematology and coagulation testingAndy Nguyen, Amer Wahed
Chapter 20. Challenges in Clinical Microbiology TestingLaura Chandler
Chapter 21. Sources of errors in molecular testingLaura Chandler
Chapter 22. Problems in Pharmacogenomics TestingDina N Greene, Cecily Vaughn, Elaine Lyon
