Accurate Results in the Clinical Laboratory book cover

Accurate Results in the Clinical Laboratory

A Guide to Error Detection and Correction

This practical, easy-to-use guide, named to Doody’s Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care.

Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management.


Pathologists, clinical chemists, and toxicologists; practicing clinicians, fellows and residents in pathology, internal medicine, emergency medicine and family practice.

Hardbound, 382 Pages

Published: February 2013

Imprint: Elsevier

ISBN: 978-0-12-415783-5


  • "Dasgupta and Sepulveda offer clinicians and laboratory scientists a guide to error detection and correction in the clinical laboratory that addresses sources of errors in analytical methods and sources of pre-analytical variation."--Reference and Research Book News, August 2013
    "This is a very helpful book correlating nonanalytical measurement errors or disease states with anticipated effects on laboratory test results. This would be a must for the laboratory medicine resident who has to explain why results don't correlate with clinical disease.", August 9, 2013


  • Chapter 1. Variation, Errors, and Quality in the Clinical Laboratory

    Jorge Sepulveda

    Chapter 2. Effect of Age, Gender, Diet, Exercise and Ethnicity on Laboratory Test Results

    Octavia M. Peck Palmer

    Chapter 3. Effect of patient preparation, specimen collection, anticoagulants and preservatives on laboratory tests

    Leland Baskin, Valerian Dias, Alex Chin, Amid Abdullah and Christopher Naugler

    Chapter 4. Sample processing and specimen misidentification issues

    Alison Woodworth and Amy L. Pyle

    Chapter 5. Hemolysis, lipemia and high bilirubin: effect on laboratory tests

    Steven C. Kazmierczak

    Chapter 6. Immunoassay design and mechanism of interferences

    Pradip Datta

    Chapter 7. Effect of herbal remedies on clinical laboratory tests

    Amitava Dasgupta

    Chapter 8. Challenges in routine clinical chemistry: analysis of small molecules

    Jorge Sepulveda

    Chapter 9. Challenges in routine clinical chemistry: proteins and enzymes

    Jorge Sepulveda

    Chapter 10. Sources of inaccuracy in biochemical genetics analysis

    Michael J. Bennett

    Chapter 11. Challenges in endocrinology testing

    Lindsay A. L. Bazydlo, Neil S. Harris and William E. Winter

    Chapter 12. Pitfalls in tumor marker testing

    Alyaa Al-Ibraheemi, Amitava Dasgupta, and Amer Wahed, M.D

    Chapter 13. Issues of interferences in therapeutic drug monitoring

    Gwendolyn A. McMillin, and Kamisha L. Johnson-Davis

    Chapter 14. Limitations of drugs of abuse testing

    Amitava Dasgupta

    Chapter 15. Challenges in confirmation testing for drugs of abuse

    Larry A. Broussard

    Chapter 16. Alcohol determination using automated analyzers: limitations and pitfalls

    Sheila Dawling

    Chapter 17. Pre-analytical issues and interferences in transfusion medicine tests

    Elena Nedelcu

    Chapter 18. Critical issues in immunology and serology testing

    Amer Wahed, Semyon Risin

    Chapter 19. Sources of errors in hematology and coagulation testing

    Andy Nguyen, Amer Wahed

    Chapter 20. Challenges in Clinical Microbiology Testing

    Laura Chandler

    Chapter 21. Sources of errors in molecular testing

    Laura Chandler

    Chapter 22. Problems in Pharmacogenomics Testing

    Dina N Greene, Cecily Vaughn, Elaine Lyon


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