Accurate Results in the Clinical Laboratory

A Guide to Error Detection and Correction

Edited by

  • Amitava Dasgupta, Professor, Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX, USA
  • Jorge Sepulveda, MD, PhD, Associate Professor and Associate Director of Laboratory Medicine, Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA

This practical, easy-to-use guide, named to Doody’s Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care.

Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management.

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Pathologists, clinical chemists, and toxicologists; practicing clinicians, fellows and residents in pathology, internal medicine, emergency medicine and family practice.


Book information

  • Published: February 2013
  • Imprint: ELSEVIER
  • ISBN: 978-0-12-415783-5


"Dasgupta and Sepulveda offer clinicians and laboratory scientists a guide to error detection and correction in the clinical laboratory that addresses sources of errors in analytical methods and sources of pre-analytical variation."--Reference and Research Book News, August 2013
"This is a very helpful book correlating nonanalytical measurement errors or disease states with anticipated effects on laboratory test results. This would be a must for the laboratory medicine resident who has to explain why results don't correlate with clinical disease.", August 9, 2013

Table of Contents

Chapter 1. Variation, Errors, and Quality in the Clinical Laboratory

Jorge Sepulveda

Chapter 2. Effect of Age, Gender, Diet, Exercise and Ethnicity on Laboratory Test Results

Octavia M. Peck Palmer

Chapter 3. Effect of patient preparation, specimen collection, anticoagulants and preservatives on laboratory tests

Leland Baskin, Valerian Dias, Alex Chin, Amid Abdullah and Christopher Naugler

Chapter 4. Sample processing and specimen misidentification issues

Alison Woodworth and Amy L. Pyle

Chapter 5. Hemolysis, lipemia and high bilirubin: effect on laboratory tests

Steven C. Kazmierczak

Chapter 6. Immunoassay design and mechanism of interferences

Pradip Datta

Chapter 7. Effect of herbal remedies on clinical laboratory tests

Amitava Dasgupta

Chapter 8. Challenges in routine clinical chemistry: analysis of small molecules

Jorge Sepulveda

Chapter 9. Challenges in routine clinical chemistry: proteins and enzymes

Jorge Sepulveda

Chapter 10. Sources of inaccuracy in biochemical genetics analysis

Michael J. Bennett

Chapter 11. Challenges in endocrinology testing

Lindsay A. L. Bazydlo, Neil S. Harris and William E. Winter

Chapter 12. Pitfalls in tumor marker testing

Alyaa Al-Ibraheemi, Amitava Dasgupta, and Amer Wahed, M.D

Chapter 13. Issues of interferences in therapeutic drug monitoring

Gwendolyn A. McMillin, and Kamisha L. Johnson-Davis

Chapter 14. Limitations of drugs of abuse testing

Amitava Dasgupta

Chapter 15. Challenges in confirmation testing for drugs of abuse

Larry A. Broussard

Chapter 16. Alcohol determination using automated analyzers: limitations and pitfalls

Sheila Dawling

Chapter 17. Pre-analytical issues and interferences in transfusion medicine tests

Elena Nedelcu

Chapter 18. Critical issues in immunology and serology testing

Amer Wahed, Semyon Risin

Chapter 19. Sources of errors in hematology and coagulation testing

Andy Nguyen, Amer Wahed

Chapter 20. Challenges in Clinical Microbiology Testing

Laura Chandler

Chapter 21. Sources of errors in molecular testing

Laura Chandler

Chapter 22. Problems in Pharmacogenomics Testing

Dina N Greene, Cecily Vaughn, Elaine Lyon