ABC Proteins book cover

ABC Proteins

From Bacteria to Man

Audience
Biochemists, microbiologists, molecular biologists, cell biologists, and geneticists

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Published: December 2002

Imprint: Academic Press

ISBN: 978-0-12-352551-2

Reviews

  • "...the volume unquestionably succeeds overall as an in-depth survey of both the biology and the biochemistry of a ubiquitous and astonishingly diverse family of very complex enzymes. Every group with an interest in these proteins should own a copy." -CELL (July 2003) "The editors of ABC Proteins: From Bacteria to Man have valiantly attempted to encompass in this volume the entire scope of research on these proteins, from atomic-resolution structure to human genetic diseases, and from Escherichia coli to Homo sapiens and Arabidopsis thaliana... What the book makes obvious is that nearly all ABC proteins are membrane localized, ATP dependent, primary active transporters...In addition to advances in our understanding of ABC transporter structure, several chapters in the book also describe progress that has been made in elcuidating the mechanisms of transport. The volume unquestionably succeeds overall as an in-depth survey of both the biology and the biochemistry of a ubiquitous and astoundingly diverse family of very complex enzymes. Every group with an interest in these proteins should own a copy. Finally, this book makes a convincing case that many laboratories that may not yet suspect it will soon have a much more abiding interest in ABC proteins." "...well organized and included beautifully clear color images and figures." -E STREAMS (July 2003)

Contents

  • PrefaceIntroduction PART 1-PHYLOGENY AND EVOLUTION OF ABC-TRANSPORTERSPhylogenetic and Functional Classification of ABC (ATP-binding cassette) SystemsMembrane Topology of the Human ABC Transporter ProteinsHuman and Drosophila ABC-Proteins PART 2-FUNDAMENTAL ASPECTS OF THE MECHANISM OF ACTION OF ABC-TRANSPORTERSStructure and Modular Organization of ABC-TransportersSubstrate Binding Sites in ABC-TransportersProbing of Conformational Changes,Catalytic Cycle and ABC-Transporters FunctionX-ray Structure of an Intact ABC-Transporter, MsbAPART 3-PROKARYOTE ABC-TRANSPORTERSIntroduction to Bacterial ABC-Transport SystemsImport of Solutes by ABC-Transporters-The Maltose SystemCrystal Structures of Periplasmic Solute Binding Proteins in ABC-Transport Complexes Illuminate their FunctionBacterial ABC-Transporters Involved in Protein Translocation Bacterial Multidrug Resistance Mediated by ABC-TransportersStructure and Function of Osmoregulated ABC TransportersPART 4 -NON-MAMMALIAN EUKARYOTE ABC-TRANSPORTERSInventory & Evolution of Fungal ABC Protein GenesFungal ABC Proteins in Clinical Drug Resistance & Cellular DetoxificationDrug Resistance Mediated by ABC Transporters in Parasites of HumansThe Plant ABC Transporter Superfamily: the Functions of a Few and Identities of ManyPART 5-MAMMALIAN MULTIDRUG RESISTANCE ABC-TRANSPORTERSSolving the Problem of Multidrug Resistance: ABC Transporters in Clinical OncologyMultidrug Resistance Protein 1 (ABCC1)MRP2, the Apical Export Pump for Anionic Conjugates The Multidrug Resistance Proteins 3-7Lipid Transport by ABC TransportersRole of ABCA1 in Cell Turnover and Lipid HomeostasisPeroxisome ABC-Transporters ABC-Transporters in Mitochondria The Transporter Associated with Antigen Processing (TAP): A Peptide Transport and Loading Complex Essential for Cellular Immune ResponsesThe Sulphonylurea Receptor: an ABCC Transporter that Acts as an Ion Channel RegulatorABC-Transporters and Human Eye DiseaseStructure Function Analysis of CFTR

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