A Historical Perspective on Evidence-Based Immunology

Edited by

  • Edward Moticka, Professor, Department of Immunology and Microbiology, A.T. Still University School of Osteopathic Medicine, Mesa, AZ, U.S.A.

A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights.

The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen−TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells.

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graduate and undergraduate students entering the fields of immunology, molecular biology and other biomedical disciplines, their instructors and mentors. Researchers, practitioners and those interested in the evolution of ideas and scientific methods will find the text compelling and useful.


Book information

  • Published: December 2015
  • Imprint: ELSEVIER
  • ISBN: 978-0-12-398381-7

Table of Contents

1. Evidence that small lymphocytes are antigen-specific immune cells.
2. Evidence that plasma cells (antibody producing cells) are derived from small lymphocytes.
3. Evidence that not all immunity involves antibody.
4. The concept on one cell: one antibody.
5. The concept of selection - the clonal selection theory.
6. Immunologic tolerance.
7. Evidence that the thymus plays a role in the immune response.
8. The role of the burse of Fabricius in the immune response and the search for the human equivalent of the bursa.
9. Cellular interactions in the immune response - two cells required to make antibody.
10. Cellular interactions in the immune response - three ceels are better than two.
11. Interactions of lymphocytes with antigen - TCR and BCR.
12. The identification of antigen presenting cells and the mechanism of antigen presentation. Role of MHC I and MHC II in presenting antigen.
13. Division of T cells into subpopulations.
14. Identification of co-stimulatory molecules in cell interactions.
15. Generation of diversity - B cells.
16. Mechanism of B cell tolerance.
17. Generation of diversity - T cells.
18. Mechanism of T cell tolerance.
19. Mechanism of B cell isotype switching.
20. The first cytokines and the concepts of intercellular signaling.
21. Recognition in the innate immune response.
22. Efffector mechanism - antibody.
23. Effector mechanism - T cells.
24 Concept of autoimmunity (the death of horror autotoxicus).
25. Allergy and the identification of IgE.
26. Congenital immunodeficiencies - initial observations and mechanisms.
27. Immunoproliferation disease - pathology of the normal; monoclonal gammopathies and unknown origin.
28. Identification of NK cells as a unique cell type.
29. T cell control of the immune response - from suppression to regulation. (new)
30. Evidence that seruim contains two substances involved in anti-bacterial immunity.
31. Antibody molecules are monospecific; development of monoclonal antibodies.
32. Structure of antibody molecules - identification of Fab and Fc regions; division into H and L chains.
33. Differentiation of immunoglobulin isotopes.
34. Mechanisms of antibody action.
35. Evidence that HLA molecules are coded by genes the MHC.
36. Functions of HLA molecules.
37. NK cells and antibody dependent cell-mediated cytotoxicity.
38. Dendritic cells.