A Historical Perspective on Evidence-Based Immunology
A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to current understanding of immunological principles. This book helps beginning students in biomedical disciplines to understand the basis of immunologic knowledge and more advanced students to gain further insight. It also serves as a crucial reference for researchers studying the evolution of ideas and scientific methods.
Among the fundamental insights covered in the book are:
- Immunologic tolerance
- Interactions of lymphocytes with antigen - TCR and BCR
- Generation of diversity and mechanism of tolerance of T cells and B cells
- The first cytokines
- The concept of autoimmunity
- Identification of NK cells as a unique cell type
- The structure of antibody molecules and identification of Fab and Fc regions
- Dendritic cells
graduate and undergraduate students entering the fields of immunology, molecular biology and other biomedical disciplines, their instructors and mentors. Researchers, practitioners and those interested in the evolution of ideas and scientific methods will find the text compelling and useful.